Names & Taxonomy

Uniprot ID:
P06729
Entry Name:
CD2_HUMAN
Status:
reviewed
Protein Names:
T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)
Gene Names:
CD2 SRBC
Gene Names Primary:
CD2
Organism:
Homo sapiens (Human)

Structure

Length:
351
Sequence:
MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Cross Reference Drug Bank:
DB00092
Gene Ontology Go:
anchored component of plasma membrane
cell surface
cell-cell junction
cytoplasmic side of plasma membrane
external side of plasma membrane
extracellular region
integral component of plasma membrane
plasma membrane
receptor activity
receptor binding
apoptotic process
blood coagulation
cell surface receptor signaling pathway
heterotypic cell-cell adhesion
leukocyte migration
membrane raft polarization
natural killer cell activation
positive regulation of interferon-gamma secretion
positive regulation of interleukin-8 secretion
positive regulation of myeloid dendritic cell activation
positive regulation of tumor necrosis factor production
regulation of T cell differentiation
single organismal cell-cell adhesion
T cell activation
Gene Ontology Biological Process:
apoptotic process
blood coagulation
cell surface receptor signaling pathway
heterotypic cell-cell adhesion
leukocyte migration
membrane raft polarization
natural killer cell activation
positive regulation of interferon-gamma secretion
positive regulation of interleukin-8 secretion
positive regulation of myeloid dendritic cell activation
positive regulation of tumor necrosis factor production
regulation of T cell differentiation
single organismal cell-cell adhesion
T cell activation
Gene Ontology Molecular Function:
receptor activity
receptor binding
Gene Ontology Cellular Component:
anchored component of plasma membrane
cell-cell junction
cell surface
cytoplasmic side of plasma membrane
external side of plasma membrane
extracellular region
integral component of plasma membrane
plasma membrane
Keywords:
3D-structure
Cell adhesion
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Interacts With:
Q9Y5K6; O95400; Q96B97

Publication

PubMed ID:
2894031 2437578 3490670 2883656 2901953 16710414 15489334 2444890 1377404 9857189 7994575 7915183 7544493 16959974