Names & Taxonomy
- Uniprot ID:
- P06576
- Entry Name:
- ATPB_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP synthase subunit beta, mitochondrial (EC 3.6.3.14)
- Gene Names:
- ATP5B ATPMB ATPSB
- Gene Names Primary:
- ATP5B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 529
- Sequence:
- MLGFVGRVAAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHMGKLVPLKETIKGFQQILAGEYDHLPEQAFYMVGPIEEAVAKADKLAEEHSS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.
Function
- Function:
- Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
- Catalytic Activity:
- ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
- Gene Ontology Go:
- cell surface
extracellular exosome
membrane
mitochondrial matrix
mitochondrial membrane
mitochondrial nucleoid
mitochondrial proton-transporting ATP synthase complex
mitochondrial proton-transporting ATP synthase, catalytic core
mitochondrion
myelin sheath
nucleus
plasma membrane
ATP binding
MHC class I protein binding
proton-transporting ATP synthase activity, rotational mechanism
proton-transporting ATPase activity, rotational mechanism
transmembrane transporter activity
transporter activity
angiogenesis
ATP biosynthetic process
ATP hydrolysis coupled proton transport
cellular metabolic process
generation of precursor metabolites and energy
lipid metabolic process
mitochondrial ATP synthesis coupled proton transport
mitochondrion organization
negative regulation of cell adhesion involved in substrate-bound cell migration
organelle organization
osteoblast differentiation
proton transport
regulation of intracellular pH
respiratory electron transport chain
small molecule metabolic process - Gene Ontology Biological Process:
- angiogenesis
ATP biosynthetic process
ATP hydrolysis coupled proton transport
cellular metabolic process
generation of precursor metabolites and energy
lipid metabolic process
mitochondrial ATP synthesis coupled proton transport
mitochondrion organization
negative regulation of cell adhesion involved in substrate-bound cell migration
organelle organization
osteoblast differentiation
proton transport
regulation of intracellular pH
respiratory electron transport chain
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
MHC class I protein binding
proton-transporting ATPase activity, rotational mechanism
proton-transporting ATP synthase activity, rotational mechanism
transmembrane transporter activity
transporter activity - Gene Ontology Cellular Component:
- cell surface
extracellular exosome
membrane
mitochondrial matrix
mitochondrial membrane
mitochondrial nucleoid
mitochondrial proton-transporting ATP synthase, catalytic core
mitochondrial proton-transporting ATP synthase complex
mitochondrion
myelin sheath
nucleus
plasma membrane - Keywords:
- ATP synthesis
ATP-binding
Acetylation
CF(1)
Complete proteome
Direct protein sequencing
Glycoprotein
Hydrogen ion transport
Hydrolase
Ion transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide
Transport - Interacts With:
- P63104