Names & Taxonomy
- Uniprot ID:
- P05556
- Entry Name:
- ITB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)
- Gene Names:
- ITGB1 FNRB MDF2 MSK12
- Gene Names Primary:
- ITGB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 798
- Sequence:
- MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion.
- Cross Reference Drug Bank:
- DB00098
- Gene Ontology Go:
- acrosomal vesicle
basement membrane
cell surface
cleavage furrow
cytoplasm
dendritic spine
external side of plasma membrane
extracellular exosome
filopodium
focal adhesion
hemidesmosome
integrin alpha1-beta1 complex
integrin alpha10-beta1 complex
integrin alpha11-beta1 complex
integrin alpha2-beta1 complex
integrin alpha3-beta1 complex
integrin alpha7-beta1 complex
integrin alpha8-beta1 complex
integrin alpha9-beta1 complex
integrin complex
intercalated disc
invadopodium membrane
lamellipodium
melanosome
membrane
membrane raft
myelin sheath abaxonal region
neuromuscular junction
perinuclear region of cytoplasm
plasma membrane
receptor complex
recycling endosome
ruffle
ruffle membrane
sarcolemma
synaptic membrane
actin binding
cell adhesion molecule binding
collagen binding involved in cell-matrix adhesion
fibronectin binding
metal ion binding
peptide binding
protease binding
protein complex binding
protein heterodimerization activity
virus receptor activity
axon extension
axon guidance
B cell differentiation
bicellular tight junction assembly
blood coagulation
calcium-independent cell-matrix adhesion
cardiac muscle cell differentiation
cell fate specification
cell junction assembly
cell migration
cell migration involved in sprouting angiogenesis
cell-cell adhesion mediated by integrin
cell-matrix adhesion
cell-substrate adhesion
cellular calcium ion homeostasis
cellular defense response
cellular response to ionizing radiation
cellular response to low-density lipoprotein particle stimulus
cellular response to mechanical stimulus
cellular response to vitamin D
dendrite morphogenesis
extracellular matrix organization
formation of radial glial scaffolds
G1/S transition of mitotic cell cycle
germ cell migration
heterotypic cell-cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
in utero embryonic development
integrin-mediated signaling pathway
leukocyte cell-cell adhesion
leukocyte migration
leukocyte tethering or rolling
maternal process involved in female pregnancy
mesodermal cell differentiation
negative regulation of anoikis
negative regulation of cell projection organization
negative regulation of cell proliferation
negative regulation of neuron differentiation
negative regulation of Rho protein signal transduction
positive regulation of apoptotic process
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of cell-substrate adhesion
positive regulation of endocytosis
positive regulation of establishment of protein localization to plasma membrane
positive regulation of GTPase activity
positive regulation of MAPK cascade
positive regulation of neuron projection development
positive regulation of peptidyl-tyrosine phosphorylation
protein transport within lipid bilayer
receptor internalization
regulation of cell cycle
regulation of collagen catabolic process
regulation of G-protein coupled receptor protein signaling pathway
regulation of immune response
response to activity
response to drug
response to gonadotropin
response to transforming growth factor beta
sarcomere organization
small GTPase mediated signal transduction
tissue homeostasis
visual learning - Gene Ontology Biological Process:
- axon extension
axon guidance
B cell differentiation
bicellular tight junction assembly
blood coagulation
calcium-independent cell-matrix adhesion
cardiac muscle cell differentiation
cell-cell adhesion mediated by integrin
cell fate specification
cell junction assembly
cell-matrix adhesion
cell migration
cell migration involved in sprouting angiogenesis
cell-substrate adhesion
cellular calcium ion homeostasis
cellular defense response
cellular response to ionizing radiation
cellular response to low-density lipoprotein particle stimulus
cellular response to mechanical stimulus
cellular response to vitamin D
dendrite morphogenesis
extracellular matrix organization
formation of radial glial scaffolds
G1/S transition of mitotic cell cycle
germ cell migration
heterotypic cell-cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
integrin-mediated signaling pathway
in utero embryonic development
leukocyte cell-cell adhesion
leukocyte migration
leukocyte tethering or rolling
maternal process involved in female pregnancy
mesodermal cell differentiation
negative regulation of anoikis
negative regulation of cell projection organization
negative regulation of cell proliferation
negative regulation of neuron differentiation
negative regulation of Rho protein signal transduction
positive regulation of apoptotic process
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of cell-substrate adhesion
positive regulation of endocytosis
positive regulation of establishment of protein localization to plasma membrane
positive regulation of GTPase activity
positive regulation of MAPK cascade
positive regulation of neuron projection development
positive regulation of peptidyl-tyrosine phosphorylation
protein transport within lipid bilayer
receptor internalization
regulation of cell cycle
regulation of collagen catabolic process
regulation of G-protein coupled receptor protein signaling pathway
regulation of immune response
response to activity
response to drug
response to gonadotropin
response to transforming growth factor beta
sarcomere organization
small GTPase mediated signal transduction
tissue homeostasis
visual learning - Gene Ontology Molecular Function:
- actin binding
cell adhesion molecule binding
collagen binding involved in cell-matrix adhesion
fibronectin binding
metal ion binding
peptide binding
protease binding
protein complex binding
protein heterodimerization activity
virus receptor activity - Gene Ontology Cellular Component:
- acrosomal vesicle
basement membrane
cell surface
cleavage furrow
cytoplasm
dendritic spine
external side of plasma membrane
extracellular exosome
filopodium
focal adhesion
hemidesmosome
integrin alpha10-beta1 complex
integrin alpha11-beta1 complex
integrin alpha1-beta1 complex
integrin alpha2-beta1 complex
integrin alpha3-beta1 complex
integrin alpha7-beta1 complex
integrin alpha8-beta1 complex
integrin alpha9-beta1 complex
integrin complex
intercalated disc
invadopodium membrane
lamellipodium
melanosome
membrane
membrane raft
myelin sheath abaxonal region
neuromuscular junction
perinuclear region of cytoplasm
plasma membrane
receptor complex
recycling endosome
ruffle
ruffle membrane
sarcolemma
synaptic membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing
Disulfide bond
Endosome
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Integrin
Magnesium
Membrane
Metal-binding
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Q9BY76; P03192; P32927; P17813; P05413; P21333; P17301; P13612; P07948; P18031; P49023; P35282; Q9Y490
Publication
- PubMed ID:
- 2958481 14702039 17974005 15164054 15489334 7681433 7523423 2249781 1551917 7545396 7544298 9494094 15276642 8411387 8567725 9501082 10397733 10455171 10613898 11741838 11919189 11807098 11807099 12907437 12473654 12695522 12941907 14722085 15181153 15156152 16256741 16076904 16335952 16754960 17081065 16501085 17956333 17925226 18804435 19064666 17945327 19159218 19349973 19690332 19608861 20660204 21269460 22027826 21768292 21325030 24275569 25944712 22645133 22451694 23317506