Names & Taxonomy
- Uniprot ID:
- P05186
- Entry Name:
- PPBT_HUMAN
- Status:
- reviewed
- Protein Names:
- Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)
- Gene Names:
- ALPL
- Gene Names Primary:
- ALPL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 524
- Sequence:
- MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- This isozyme may play a role in skeletal mineralization.
- Catalytic Activity:
- A phosphate monoester + H(2)O = an alcohol + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 110 110 Phosphoserine intermediate.
- Cross Reference Drug Bank:
- DB01143 DB06716
- Gene Ontology Go:
- anchored component of membrane
extracellular exosome
extracellular space
integral component of membrane
membrane
plasma membrane
proteinaceous extracellular matrix
alkaline phosphatase activity
metal ion binding
pyrophosphatase activity
cellular response to organic cyclic compound
cementum mineralization
developmental process involved in reproduction
endochondral ossification
osteoblast differentiation
response to antibiotic
response to glucocorticoid
response to lipopolysaccharide
response to vitamin D
skeletal system development - Gene Ontology Biological Process:
- cellular response to organic cyclic compound
cementum mineralization
developmental process involved in reproduction
endochondral ossification
osteoblast differentiation
response to antibiotic
response to glucocorticoid
response to lipopolysaccharide
response to vitamin D
skeletal system development - Gene Ontology Molecular Function:
- alkaline phosphatase activity
metal ion binding
pyrophosphatase activity - Gene Ontology Cellular Component:
- anchored component of membrane
extracellular exosome
extracellular space
integral component of membrane
membrane
plasma membrane
proteinaceous extracellular matrix - Keywords:
- Alternative splicing
Biomineralization
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
GPI-anchor
Glycoprotein
Hydrolase
Lipoprotein
Magnesium
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Signal
Transmembrane
Zinc - Interacts With:
- Q99558
Publication
- PubMed ID:
- 3532105 3165380 2928120 9747027 14702039 16710414 15489334 3954357 1458595 14517339 16602701 19159218 21406692 3174660 1409720 8406453 7833929 8954059 9781036 9452105 10332035 10094560 10834525 10679946 10690885 11745997 11479741 11438998 11760847 11834095 11999978 11855933 12815606 12920074 15135428 15694177 19500388 22266140 23039266 23688511 25982064