Names & Taxonomy
- Uniprot ID:
- P05120
- Entry Name:
- PAI2_HUMAN
- Status:
- reviewed
- Protein Names:
- Plasminogen activator inhibitor 2 (PAI-2) (Monocyte Arg-serpin) (Placental plasminogen activator inhibitor) (Serpin B2) (Urokinase inhibitor)
- Gene Names:
- SERPINB2 PAI2 PLANH2
- Gene Names Primary:
- SERPINB2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 415
- Sequence:
- MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Secreted, extracellular space.
Function
- Function:
- Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.
- Cross Reference Drug Bank:
- DB00031 DB00013
- Gene Ontology Go:
- cytoplasm
extracellular region
extracellular space
plasma membrane
serine-type endopeptidase inhibitor activity
blood coagulation
fibrinolysis
negative regulation of apoptotic process
negative regulation of endopeptidase activity - Gene Ontology Biological Process:
- blood coagulation
fibrinolysis
negative regulation of apoptotic process
negative regulation of endopeptidase activity - Gene Ontology Molecular Function:
- serine-type endopeptidase inhibitor activity
- Gene Ontology Cellular Component:
- cytoplasm
extracellular region
extracellular space
plasma membrane - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Plasminogen activation
Polymorphism
Protease inhibitor
Reference proteome
Secreted
Serine protease inhibitor
Signal