Names & Taxonomy

Uniprot ID:
P05091
Entry Name:
ALDH2_HUMAN
Status:
reviewed
Protein Names:
Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI)
Gene Names:
ALDH2 ALDM
Gene Names Primary:
ALDH2
Organism:
Homo sapiens (Human)

Structure

Length:
517
Sequence:
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix.

Function

Pathway:
Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Catalytic Activity:
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
Active Site:
ACT_SITE 285 285 Proton acceptor.; ACT_SITE 319 319 Nucleophile.
Cross Reference Drug Bank:
DB01612 DB06770 DB00822 DB00536 DB00435 DB00727
Gene Ontology Go:
extracellular exosome
mitochondrial matrix
aldehyde dehydrogenase (NAD) activity
aldehyde dehydrogenase activity
electron carrier activity
alcohol metabolic process
carbohydrate metabolic process
ethanol catabolic process
ethanol oxidation
neurotransmitter biosynthetic process
small molecule metabolic process
synaptic transmission
xenobiotic metabolic process
Gene Ontology Biological Process:
alcohol metabolic process
carbohydrate metabolic process
ethanol catabolic process
ethanol oxidation
neurotransmitter biosynthetic process
small molecule metabolic process
synaptic transmission
xenobiotic metabolic process
Gene Ontology Molecular Function:
aldehyde dehydrogenase (NAD) activity
aldehyde dehydrogenase activity
electron carrier activity
Gene Ontology Cellular Component:
extracellular exosome
mitochondrial matrix
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Mitochondrion
NAD
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide

Publication

PubMed ID:
3582651 3562250 2838413 14702039 16541075 15489334 4065146 2987944 4015823 15242332 3610592 3653404 21269460 24275569 10631996 6582480 8561277