Names & Taxonomy
- Uniprot ID:
- P05091
- Entry Name:
- ALDH2_HUMAN
- Status:
- reviewed
- Protein Names:
- Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI)
- Gene Names:
- ALDH2 ALDM
- Gene Names Primary:
- ALDH2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 517
- Sequence:
- MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Pathway:
- Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
- Catalytic Activity:
- An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
- Active Site:
- ACT_SITE 285 285 Proton acceptor.; ACT_SITE 319 319 Nucleophile.
- Cross Reference Drug Bank:
- DB01612 DB06770 DB00822 DB00536 DB00435 DB00727
- Gene Ontology Go:
- extracellular exosome
mitochondrial matrix
aldehyde dehydrogenase (NAD) activity
aldehyde dehydrogenase activity
electron carrier activity
alcohol metabolic process
carbohydrate metabolic process
ethanol catabolic process
ethanol oxidation
neurotransmitter biosynthetic process
small molecule metabolic process
synaptic transmission
xenobiotic metabolic process - Gene Ontology Biological Process:
- alcohol metabolic process
carbohydrate metabolic process
ethanol catabolic process
ethanol oxidation
neurotransmitter biosynthetic process
small molecule metabolic process
synaptic transmission
xenobiotic metabolic process - Gene Ontology Molecular Function:
- aldehyde dehydrogenase (NAD) activity
aldehyde dehydrogenase activity
electron carrier activity - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrial matrix - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Mitochondrion
NAD
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide