Names & Taxonomy

Uniprot ID:
P05023
Entry Name:
AT1A1_HUMAN
Status:
reviewed
Protein Names:
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
Gene Names:
ATP1A1
Gene Names Primary:
ATP1A1
Organism:
Homo sapiens (Human)

Structure

Length:
1023
Sequence:
MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Catalytic Activity:
ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).
Active Site:
ACT_SITE 376 376 4-aspartylphosphate intermediate.
Cross Reference Drug Bank:
DB00511 DB01430 DB01370 DB01244 DB01158 DB01188 DB01078 DB01119 DB01396 DB00390 DB00903 DB00774 DB01092 DB01345 DB01021
Gene Ontology Go:
apical plasma membrane
basolateral plasma membrane
caveola
endoplasmic reticulum
endosome
extracellular exosome
extracellular vesicle
Golgi apparatus
integral component of membrane
intercalated disc
intracellular membrane-bounded organelle
melanosome
membrane
myelin sheath
neuronal postsynaptic density
plasma membrane
protein complex
sarcolemma
sodium:potassium-exchanging ATPase complex
T-tubule
ADP binding
ATP binding
chaperone binding
phosphatase activity
potassium ion binding
sodium ion binding
sodium:potassium-exchanging ATPase activity
steroid hormone binding
ATP hydrolysis coupled proton transport
cardiac conduction
cardiac muscle contraction
cell communication by electrical coupling involved in cardiac conduction
cellular potassium ion homeostasis
cellular response to mechanical stimulus
cellular response to steroid hormone stimulus
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
membrane hyperpolarization
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
negative regulation of glucocorticoid biosynthetic process
negative regulation of heart contraction
positive regulation of heart contraction
positive regulation of striated muscle contraction
potassium ion import
potassium ion import across plasma membrane
regulation of blood pressure
regulation of cardiac conduction
regulation of cardiac muscle cell contraction
regulation of sodium ion transport
regulation of the force of heart contraction
relaxation of cardiac muscle
response to drug
response to glycoside
sodium ion export from cell
transmembrane transport
Gene Ontology Biological Process:
ATP hydrolysis coupled proton transport
cardiac conduction
cardiac muscle contraction
cell communication by electrical coupling involved in cardiac conduction
cellular potassium ion homeostasis
cellular response to mechanical stimulus
cellular response to steroid hormone stimulus
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
membrane hyperpolarization
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
negative regulation of glucocorticoid biosynthetic process
negative regulation of heart contraction
positive regulation of heart contraction
positive regulation of striated muscle contraction
potassium ion import
potassium ion import across plasma membrane
regulation of blood pressure
regulation of cardiac conduction
regulation of cardiac muscle cell contraction
regulation of sodium ion transport
regulation of the force of heart contraction
relaxation of cardiac muscle
response to drug
response to glycoside
sodium ion export from cell
transmembrane transport
Gene Ontology Molecular Function:
ADP binding
ATP binding
chaperone binding
phosphatase activity
potassium ion binding
sodium:potassium-exchanging ATPase activity
sodium ion binding
steroid hormone binding
Gene Ontology Cellular Component:
apical plasma membrane
basolateral plasma membrane
caveola
endoplasmic reticulum
endosome
extracellular exosome
extracellular vesicle
Golgi apparatus
integral component of membrane
intercalated disc
intracellular membrane-bounded organelle
melanosome
membrane
myelin sheath
neuronal postsynaptic density
plasma membrane
protein complex
sarcolemma
sodium:potassium-exchanging ATPase complex
T-tubule
Keywords:
ATP-binding
Acetylation
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Potassium
Potassium transport
Reference proteome
Sodium
Sodium transport
Sodium/potassium transport
Transmembrane
Transmembrane helix
Transport
Interacts With:
P13693

Publication

PubMed ID:
2430951 7536695 14702039 16710414 15489334 1970326 3035563 2891135 1380674 3036582 7711835 14759258 17081065 19413330 19690332 21269460 22084111 24275569 25944712