Names & Taxonomy

Uniprot ID:
P04798
Entry Name:
CP1A1_HUMAN
Status:
reviewed
Protein Names:
Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (Cytochrome P450 form 6) (Cytochrome P450-C) (Cytochrome P450-P1)
Gene Names:
CYP1A1
Gene Names Primary:
CYP1A1
Organism:
Homo sapiens (Human)

Structure

Length:
512
Sequence:
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Function

Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic Activity:
RH + + O(2) = ROH + + H(2)O.
Cofactor:
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
Cross Reference Drug Bank:
DB00316 DB00518 DB01118 DB00381 DB00613 DB01169 DB00972 DB06770 DB01393 DB00188 DB00201 DB01136 DB00608 DB00356 DB00169 DB00568 DB01407 DB01013 DB00636 DB00882 DB00575 DB00363 DB00851 DB06292 DB01254 DB00694 DB04840 DB01234 DB00633 DB00586 DB00804 DB00470 DB00530 DB00783 DB00655 DB00898 DB04841 DB00693 DB00499 DB01095 DB00176 DB00317 DB00889 DB00502 DB01064 DB01167 DB01026 DB00448 DB04871 DB00643 DB01065 DB00170 DB00553 DB00184 DB01115 DB00325 DB01059 DB00338 DB01092 DB00526 DB00738 DB01174 DB00457 DB01087 DB00396 DB00818 DB00571 DB00165 DB00908 DB00468 DB01129 DB00740 DB00203 DB00428 DB00605 DB00675 DB00624 DB01041 DB00277 DB00730 DB00208 DB00539 DB00755 DB00162 DB00682
Gene Ontology Go:
endoplasmic reticulum membrane
intracellular membrane-bounded organelle
mitochondrion
aromatase activity
demethylase activity
flavonoid 3'-monooxygenase activity
heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on diphenols and related substances as donors
oxygen binding
steroid hydroxylase activity
vitamin D 24-hydroxylase activity
9-cis-retinoic acid biosynthetic process
aging
amine metabolic process
arachidonic acid metabolic process
camera-type eye development
cell proliferation
cellular lipid metabolic process
cellular response to organic cyclic compound
coumarin metabolic process
dibenzo-p-dioxin catabolic process
digestive tract development
drug metabolic process
embryo development ending in birth or egg hatching
epoxygenase P450 pathway
flavonoid metabolic process
hepatocyte differentiation
hydrogen peroxide biosynthetic process
insecticide metabolic process
maternal process involved in parturition
omega-hydroxylase P450 pathway
oxidation-reduction process
porphyrin-containing compound metabolic process
positive regulation of G1/S transition of mitotic cell cycle
response to antibiotic
response to arsenic-containing substance
response to drug
response to food
response to herbicide
response to hyperoxia
response to hypoxia
response to immobilization stress
response to iron(III) ion
response to lipopolysaccharide
response to nematode
response to virus
response to vitamin A
response to wounding
small molecule metabolic process
vitamin D metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
9-cis-retinoic acid biosynthetic process
aging
amine metabolic process
arachidonic acid metabolic process
camera-type eye development
cell proliferation
cellular lipid metabolic process
cellular response to organic cyclic compound
coumarin metabolic process
dibenzo-p-dioxin catabolic process
digestive tract development
drug metabolic process
embryo development ending in birth or egg hatching
epoxygenase P450 pathway
flavonoid metabolic process
hepatocyte differentiation
hydrogen peroxide biosynthetic process
insecticide metabolic process
maternal process involved in parturition
omega-hydroxylase P450 pathway
oxidation-reduction process
porphyrin-containing compound metabolic process
positive regulation of G1/S transition of mitotic cell cycle
response to antibiotic
response to arsenic-containing substance
response to drug
response to food
response to herbicide
response to hyperoxia
response to hypoxia
response to immobilization stress
response to iron(III) ion
response to lipopolysaccharide
response to nematode
response to virus
response to vitamin A
response to wounding
small molecule metabolic process
vitamin D metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
aromatase activity
demethylase activity
flavonoid 3'-monooxygenase activity
heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on diphenols and related substances as donors
oxygen binding
steroid hydroxylase activity
vitamin D 24-hydroxylase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
intracellular membrane-bounded organelle
mitochondrion
Keywords:
3D-structure
Alternative splicing
Complete proteome
Endoplasmic reticulum
Glycoprotein
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase
Polymorphism
Reference proteome
Interacts With:
Q96DZ9

Publication

PubMed ID:
2989797 3838385 3019683 11207026 16572171 15489334 9500998 3000715 24275569 23508959 1722803 8895751 10739168 11295847 15618738 15469410 15643613 16959974