Names & Taxonomy
- Uniprot ID:
- P04746
- Entry Name:
- AMYP_HUMAN
- Status:
- reviewed
- Protein Names:
- Pancreatic alpha-amylase (PA) (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)
- Gene Names:
- AMY2A
- Gene Names Primary:
- AMY2A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 511
- Sequence:
- MKFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNENVAIYNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGNAVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLTGLLDLALEKDYVRSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNSNWFPAGSKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFVPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRQFQNGNDVNDWVGPPNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVIFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWSFSLTLQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space.
Function
- Catalytic Activity:
- Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 212 212 Nucleophile.
- Cross Reference Drug Bank:
- DB00284 DB00702 DB00491
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
alpha-amylase activity
calcium ion binding
chloride ion binding
carbohydrate catabolic process
carbohydrate metabolic process
polysaccharide digestion
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate catabolic process
carbohydrate metabolic process
polysaccharide digestion
small molecule metabolic process - Gene Ontology Molecular Function:
- alpha-amylase activity
calcium ion binding
chloride ion binding - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space - Keywords:
- 3D-structure
Alternative splicing
Calcium
Carbohydrate metabolism
Chloride
Complete proteome
Disulfide bond
Glycoprotein
Glycosidase
Hydrolase
Metal-binding
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal