Names & Taxonomy
- Uniprot ID:
- P04745
- Entry Name:
- AMY1_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-amylase 1 (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase 1) (Salivary alpha-amylase)
- Gene Names:
- AMY1A AMY1; AMY1B AMY1; AMY1C AMY1
- Gene Names Orf:
- ; ;
- Gene Names Primary:
- AMY1A; AMY1B; AMY1C
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 511
- Sequence:
- MKLFWLLFTIGFCWAQYSSNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNENVAIHNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGNAVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLSGLLDLALGKDYVRSKIAEYMNHLIDIGVAGFRIDASKHMWPGDIKAILDKLHNLNSNWFPEGSKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRYFENGKDVNDWVGPPNDNGVTKEVTINPDTTCGNDWVCEHRWRQIRNMVNFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWTFSLTLQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Catalytic Activity:
- Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 212 212 Nucleophile.; ACT_SITE 248 248 Proton donor.
- Gene Ontology Go:
- extracellular exosome
extracellular space
alpha-amylase activity
metal ion binding
carbohydrate metabolic process
digestion - Gene Ontology Biological Process:
- carbohydrate metabolic process
digestion - Gene Ontology Molecular Function:
- alpha-amylase activity
metal ion binding - Gene Ontology Cellular Component:
- extracellular exosome
extracellular space - Keywords:
- 3D-structure
Calcium
Carbohydrate metabolism
Chloride
Complete proteome
Disulfide bond
Glycoprotein
Glycosidase
Hydrolase
Metal-binding
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal - Interacts With:
- Q8TAX7