Names & Taxonomy
- Uniprot ID:
- P04637
- Entry Name:
- P53_HUMAN
- Status:
- reviewed
- Protein Names:
- Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
- Gene Names:
- TP53 P53
- Gene Names Primary:
- TP53
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 393
- Sequence:
- MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress.; Isoform 1: Nucleus. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4.; Isoform 2: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; Isoform 3: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the cytoplasm in some cells.; Isoform 4: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm following cell stress.; Isoform 7: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; Isoform 8: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli.; Isoform 9: Cytoplasm.
Function
- Function:
- Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 1 zinc ion per subunit.;
- Cross Reference Drug Bank:
- DB00945
- Gene Ontology Go:
- cytoplasm
cytosol
endoplasmic reticulum
mitochondrial matrix
mitochondrion
nuclear chromatin
nuclear matrix
nucleolus
nucleoplasm
nucleus
PML body
protein complex
replication fork
ATP binding
chaperone binding
chromatin binding
copper ion binding
core promoter sequence-specific DNA binding
damaged DNA binding
DNA binding
double-stranded DNA binding
enzyme binding
histone acetyltransferase binding
identical protein binding
p53 binding
protease binding
protein heterodimerization activity
protein kinase binding
protein N-terminus binding
protein phosphatase 2A binding
protein phosphatase binding
protein self-association
receptor tyrosine kinase binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor binding
sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
ubiquitin protein ligase binding
zinc ion binding
apoptotic process
base-excision repair
blood coagulation
cell aging
cell cycle arrest
cell differentiation
cell proliferation
cellular protein localization
cellular response to DNA damage stimulus
cellular response to drug
cellular response to glucose starvation
cellular response to hypoxia
cellular response to ionizing radiation
cellular response to UV
chromatin assembly
circadian behavior
determination of adult lifespan
DNA damage response, signal transduction by p53 class mediator
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
DNA repair
DNA strand renaturation
double-strand break repair
entrainment of circadian clock by photoperiod
ER overload response
gene expression
intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway by p53 class mediator
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
mitotic G1 DNA damage checkpoint
multicellular organism development
negative regulation of apoptotic process
negative regulation of cell growth
negative regulation of cell proliferation
negative regulation of fibroblast proliferation
negative regulation of helicase activity
negative regulation of telomerase activity
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
Notch signaling pathway
nucleotide-excision repair
oligodendrocyte apoptotic process
oxidative stress-induced premature senescence
positive regulation of apoptotic process
positive regulation of cell cycle arrest
positive regulation of execution phase of apoptosis
positive regulation of gene expression
positive regulation of histone deacetylation
positive regulation of intrinsic apoptotic signaling pathway
positive regulation of neuron apoptotic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of protein oligomerization
positive regulation of reactive oxygen species metabolic process
positive regulation of release of cytochrome c from mitochondria
positive regulation of thymocyte apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
positive regulation of transcription, DNA-templated
programmed cell death
protein complex assembly
protein localization
protein tetramerization
Ras protein signal transduction
regulation of apoptotic process
regulation of mitochondrial membrane permeability
regulation of transcription, DNA-templated
replicative senescence
response to antibiotic
response to gamma radiation
response to X-ray
transcription initiation from RNA polymerase II promoter
viral process - Gene Ontology Biological Process:
- apoptotic process
base-excision repair
blood coagulation
cell aging
cell cycle arrest
cell differentiation
cell proliferation
cellular protein localization
cellular response to DNA damage stimulus
cellular response to drug
cellular response to glucose starvation
cellular response to hypoxia
cellular response to ionizing radiation
cellular response to UV
chromatin assembly
circadian behavior
determination of adult lifespan
DNA damage response, signal transduction by p53 class mediator
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
DNA repair
DNA strand renaturation
double-strand break repair
entrainment of circadian clock by photoperiod
ER overload response
gene expression
intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway by p53 class mediator
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
mitotic G1 DNA damage checkpoint
multicellular organism development
negative regulation of apoptotic process
negative regulation of cell growth
negative regulation of cell proliferation
negative regulation of fibroblast proliferation
negative regulation of helicase activity
negative regulation of telomerase activity
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
nucleotide-excision repair
oligodendrocyte apoptotic process
oxidative stress-induced premature senescence
positive regulation of apoptotic process
positive regulation of cell cycle arrest
positive regulation of execution phase of apoptosis
positive regulation of gene expression
positive regulation of histone deacetylation
positive regulation of intrinsic apoptotic signaling pathway
positive regulation of neuron apoptotic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of protein oligomerization
positive regulation of reactive oxygen species metabolic process
positive regulation of release of cytochrome c from mitochondria
positive regulation of thymocyte apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
programmed cell death
protein complex assembly
protein localization
protein tetramerization
Ras protein signal transduction
regulation of apoptotic process
regulation of mitochondrial membrane permeability
regulation of transcription, DNA-templated
replicative senescence
response to antibiotic
response to gamma radiation
response to X-ray
transcription initiation from RNA polymerase II promoter
viral process - Gene Ontology Molecular Function:
- ATP binding
chaperone binding
chromatin binding
copper ion binding
core promoter sequence-specific DNA binding
damaged DNA binding
DNA binding
double-stranded DNA binding
enzyme binding
histone acetyltransferase binding
identical protein binding
p53 binding
protease binding
protein heterodimerization activity
protein kinase binding
protein N-terminus binding
protein phosphatase 2A binding
protein phosphatase binding
protein self-association
receptor tyrosine kinase binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor binding
sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding
ubiquitin protein ligase binding
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
endoplasmic reticulum
mitochondrial matrix
mitochondrion
nuclear chromatin
nuclear matrix
nucleolus
nucleoplasm
nucleus
PML body
protein complex
replication fork - Keywords:
- 3D-structure
Acetylation
Activator
Alternative promoter usage
Alternative splicing
Apoptosis
Biological rhythms
Cell cycle
Complete proteome
Cytoplasm
DNA-binding
Disease mutation
Endoplasmic reticulum
Glycoprotein
Host-virus interaction
Isopeptide bond
Li-Fraumeni syndrome
Metal-binding
Methylation
Mitochondrion
Necrosis
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation
Tumor suppressor
Ubl conjugation
Zinc - Interacts With:
- Itself; P03070; P26663; Q7L7W2; Q8QW27; O95376; Q9UBL3; O15169; Q8N9N5; P10415; Q07817-1; P11274; O14503; Q9NPI1; Q9BX70; Q9ESJ1; Q9BWC9; P38936; P17676; Q92793; P45481; P55060; P68400; Q14999; Q8IWT3; Q9P0U4; Q9UER7; Q92841; P17844; Q9BV47; P03126; P06463; Q09472; Q86XK2; O43524; P49841; P32780; Q13547; Q86Z02; P61978; P61978-2; P34931; P38646; P04792; P42858; Q7Z6Z7; Q16666-2; Q08619; Q92993; Q9H7Z6; Q8IZD2; Q16363; P43356; Q9UBF1; P46821; Q15759; Q8IW41; Q00987; O15151; Q9UHC7; O75970; P04731; P19338; Q9Y618; P23511; P25208; Q9Y3T9; P06748; P06748-1; Q15466; P22736; O43847; P89055; O60285; Q96FW1; Q8TEW0; P09874; Q96KB5; O75925; O75928; Q8N2W9; Q13526; P53350; P29590; P30405; P36873-1; Q8WUF5; P30153; Q13362; Q05655; P61289; Q05397; Q06609; Q96PM5; P23396; Q8N488; P23297; P29034; P26447; P04271; Q15424; Q8WTS6; P31947; Q96ST3; Q96EB6; Q923E4; Q15796; O95863; Q12772; Q96SB4; Q86TM6; P20226; P15884; Q96GM8; Q12888; Q13625; Q9H3D4; O88898; P13693; Q15672; P26687; P0CG48; Q05086; Q96PU4; Q9H9J4; Q9H9J4-2; Q93009; P11473; Q99986; Q14191; P12956; P61981; P63104; Q8TAQ5; Q9PST7
Publication
- PubMed ID:
- 4006916 2946935 3894933 3025664 2905688 1915267 8316628 11058590 16131611 11023613 14702039 16625196 15489334 14660794 6396087 2156209 2141171 1705009 1848668 8632903 8632915 9372954 9840937 10606744 10551826 10570149 10722742 10656795 10884347 11025664 10644996 10951572 11554448 11554766 11672523 11007800 11447225 11551930 11124955 11546806 11239457 12507430 11706030 11925430 11740489 11780126 12750254 12724314 12810724 12851404 12944468 12702766 15109303 15186775 15136035 15053879 15053880 15340061 15525938 14702041 16322561 15701641 15855171 16219768 15866171 17108107 16704422 16376338 16377624 17108971 16845383 16415881 17254968 17719541 17170702 17245430 17904127 18022393 17467953 17121812 17317671 17591690 17332504 17349958 17805299 17707234 17525332 18249187 18585004 18206965 17967874 19413330 19536131 19473992 19837670 19776115 19509332 19556538 19608861 20096447 20673990 20041275 20385133 19880522 20118233 20124405 20228809 20173098 20660729 21269460 21952639 20959462 21946351 21317932 22726440 22214662 22945289 22864287 24051492 23431171 25772236 8023159 7773777 9321402 8023157 7878469 8875929 8875926 14534297 16793544 16474402 16402859 20870725 8266092 1905840 8829653 17015838 18453682 18650397 18996393 19515728 20142040 20364130 1999338 1933902 1978757 2259385 1737852 1565144 1694291 1699228 2263646 1647768 1868473 1849234 1672732 1394225 1327751 1459726 1303181 1437144 1631151 7682763 8402617 8336944 8118819 8013454 7887414 8718514 8825920 8829627 9101296 9419979 9450901 9452042 10484981 10549356 11481490 12085209 16959974 17224074 17311302 25732823