Names & Taxonomy
- Uniprot ID:
- P04350
- Entry Name:
- TBB4A_HUMAN
- Status:
- reviewed
- Protein Names:
- Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain)
- Gene Names:
- TUBB4A TUBB4 TUBB5
- Gene Names Primary:
- TUBB4A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 444
- Sequence:
- MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEGEFEEEAEEEVA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton.
Function
- Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Gene Ontology Go:
- cilium
cytosol
extracellular exosome
internode region of axon
microtubule
myelin sheath
neuronal cell body
nucleus
GTP binding
GTPase activity
structural constituent of cytoskeleton
'de novo' posttranslational protein folding
cellular protein metabolic process
G2/M transition of mitotic cell cycle
microtubule-based process
mitotic cell cycle
organelle organization
protein folding - Gene Ontology Biological Process:
- 'de novo' posttranslational protein folding
cellular protein metabolic process
G2/M transition of mitotic cell cycle
microtubule-based process
mitotic cell cycle
organelle organization
protein folding - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
structural constituent of cytoskeleton - Gene Ontology Cellular Component:
- cilium
cytosol
extracellular exosome
internode region of axon
microtubule
myelin sheath
neuronal cell body
nucleus - Keywords:
- Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Dystonia
GTP-binding
Isopeptide bond
Leukodystrophy
Microtubule
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- Q5S007; P22736