Names & Taxonomy
- Uniprot ID:
- P04075
- Entry Name:
- ALDOA_HUMAN
- Status:
- reviewed
- Protein Names:
- Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase)
- Gene Names:
- ALDOA ALDA
- Gene Names Primary:
- ALDOA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 364
- Sequence:
- MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLFVSNHAY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. Note=In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+).
Function
- Function:
- Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
- Pathway:
- Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
- Catalytic Activity:
- D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=52 uM for fructose 1,6-bisphosphate (at 30 degrees Celsius)
- Active Site:
- ACT_SITE 188 188 Proton acceptor.
- Gene Ontology Go:
- actin cytoskeleton
cytosol
extracellular exosome
extracellular region
extracellular space
I band
M band
membrane
nucleus
platelet alpha granule lumen
actin binding
cytoskeletal protein binding
fructose binding
fructose-bisphosphate aldolase activity
identical protein binding
poly(A) RNA binding
tubulin binding
actin filament organization
ATP biosynthetic process
blood coagulation
canonical glycolysis
carbohydrate metabolic process
fructose 1,6-bisphosphate metabolic process
fructose metabolic process
gluconeogenesis
glucose metabolic process
glycolytic process
muscle cell cellular homeostasis
platelet activation
platelet degranulation
protein homotetramerization
regulation of cell shape
small molecule metabolic process
striated muscle contraction - Gene Ontology Biological Process:
- actin filament organization
ATP biosynthetic process
blood coagulation
canonical glycolysis
carbohydrate metabolic process
fructose 1,6-bisphosphate metabolic process
fructose metabolic process
gluconeogenesis
glucose metabolic process
glycolytic process
muscle cell cellular homeostasis
platelet activation
platelet degranulation
protein homotetramerization
regulation of cell shape
small molecule metabolic process
striated muscle contraction - Gene Ontology Molecular Function:
- actin binding
cytoskeletal protein binding
fructose binding
fructose-bisphosphate aldolase activity
identical protein binding
poly(A) RNA binding
tubulin binding - Gene Ontology Cellular Component:
- actin cytoskeleton
cytosol
extracellular exosome
extracellular region
extracellular space
I band
M band
membrane
nucleus
platelet alpha granule lumen - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Glycogen storage disease
Glycolysis
Hereditary hemolytic anemia
Lyase
Phosphoprotein
Polymorphism
Reference proteome
Schiff base - Interacts With:
- P09972; P05014; P12004
Publication
- PubMed ID:
- 3840020 3030757 3391172 1999195 14702039 15616553 15489334 3441006 3355497 6696436 12665801 1353685 3674018 17081983 18669648 18214967 19413330 19690332 19608861 20068231 21269460 21908771 21406692 22905912 22223895 22814378 24275569 25944712 2335208 2056525 10048322 2825199 2229018 8598869 14615364 14766013