Names & Taxonomy
- Uniprot ID:
- P04070
- Entry Name:
- PROC_HUMAN
- Status:
- reviewed
- Protein Names:
- Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]
- Gene Names:
- PROC
- Gene Names Primary:
- PROC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 461
- Sequence:
- MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
- Catalytic Activity:
- Degradation of blood coagulation factors Va and VIIIa.
- Active Site:
- ACT_SITE 253 253 Charge relay system.; ACT_SITE 299 299 Charge relay system.; ACT_SITE 402 402 Charge relay system.
- Cross Reference Drug Bank:
- DB00025 DB00170 DB00464
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum lumen
extracellular region
extracellular space
Golgi apparatus
Golgi lumen
calcium ion binding
serine-type endopeptidase activity
blood coagulation
cellular protein metabolic process
ER to Golgi vesicle-mediated transport
leukocyte migration
negative regulation of apoptotic process
negative regulation of blood coagulation
negative regulation of coagulation
negative regulation of inflammatory response
peptidyl-glutamic acid carboxylation
positive regulation of establishment of endothelial barrier
post-translational protein modification
proteolysis
signal peptide processing - Gene Ontology Biological Process:
- blood coagulation
cellular protein metabolic process
ER to Golgi vesicle-mediated transport
leukocyte migration
negative regulation of apoptotic process
negative regulation of blood coagulation
negative regulation of coagulation
negative regulation of inflammatory response
peptidyl-glutamic acid carboxylation
positive regulation of establishment of endothelial barrier
post-translational protein modification
proteolysis
signal peptide processing - Gene Ontology Molecular Function:
- calcium ion binding
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum lumen
extracellular region
extracellular space
Golgi apparatus
Golgi lumen - Keywords:
- 3D-structure
Alternative splicing
Blood coagulation
Calcium
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
Endoplasmic reticulum
Gamma-carboxyglutamic acid
Glycoprotein
Golgi apparatus
Hemostasis
Hydrolase
Hydroxylation
Phosphoprotein
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal
Thrombophilia
Zymogen - Interacts With:
- P51511
Publication
- PubMed ID:
- 2991859 2991887 3511471 14702039 15815621 15489334 8560401 8477066 6589623 7878626 1694179 1544894 16335952 22171320 24275569 26091039 8003977 9003757 8446940 2437584 2602169 1868249 1347706 1611081 1511988 1511989 1301959 1593215 8324221 8499565 8499568 8292730 8398832 7919373 7841323 7841324 7865674 7974343 7605880 7792728 8829639 9798967 22531345 22545135 25651845 25748729 25618265