Names & Taxonomy

Uniprot ID:
P04054
Entry Name:
PA21B_HUMAN
Status:
reviewed
Protein Names:
Phospholipase A2 (EC 3.1.1.4) (Group IB phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 1B)
Gene Names:
PLA2G1B PLA2 PLA2A PPLA2
Gene Names Primary:
PLA2G1B
Organism:
Homo sapiens (Human)

Structure

Length:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
Catalytic Activity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Active Site:
ACT_SITE 70 70
Cross Reference Drug Bank:
DB02659 DB04552 DB00795
Gene Ontology Go:
cell surface
extracellular region
extracellular space
secretory granule
bile acid binding
calcium ion binding
calcium-dependent phospholipase A2 activity
phospholipase A2 activity
receptor binding
actin filament organization
activation of MAPK activity
activation of phospholipase A2 activity
antibacterial humoral response
arachidonic acid secretion
cellular response to insulin stimulus
defense response to Gram-positive bacterium
fatty acid biosynthetic process
glucose transport
glycerophospholipid biosynthetic process
innate immune response in mucosa
interleukin-8 production
intracellular signal transduction
leukotriene biosynthetic process
multicellular organism lipid catabolic process
neutrophil chemotaxis
neutrophil mediated immunity
phosphatidic acid biosynthetic process
phosphatidylcholine acyl-chain remodeling
phosphatidylcholine metabolic process
phosphatidylethanolamine acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phospholipid metabolic process
positive regulation of calcium ion transport into cytosol
positive regulation of DNA replication
positive regulation of fibroblast proliferation
positive regulation of immune response
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein secretion
positive regulation of transcription from RNA polymerase II promoter
signal transduction
small molecule metabolic process
Gene Ontology Biological Process:
actin filament organization
activation of MAPK activity
activation of phospholipase A2 activity
antibacterial humoral response
arachidonic acid secretion
cellular response to insulin stimulus
defense response to Gram-positive bacterium
fatty acid biosynthetic process
glucose transport
glycerophospholipid biosynthetic process
innate immune response in mucosa
interleukin-8 production
intracellular signal transduction
leukotriene biosynthetic process
multicellular organism lipid catabolic process
neutrophil chemotaxis
neutrophil mediated immunity
phosphatidic acid biosynthetic process
phosphatidylcholine acyl-chain remodeling
phosphatidylcholine metabolic process
phosphatidylethanolamine acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phospholipid metabolic process
positive regulation of calcium ion transport into cytosol
positive regulation of DNA replication
positive regulation of fibroblast proliferation
positive regulation of immune response
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein secretion
positive regulation of transcription from RNA polymerase II promoter
signal transduction
small molecule metabolic process
Gene Ontology Molecular Function:
bile acid binding
calcium-dependent phospholipase A2 activity
calcium ion binding
phospholipase A2 activity
receptor binding
Gene Ontology Cellular Component:
cell surface
extracellular region
extracellular space
secretory granule
Keywords:
3D-structure
Autocatalytic cleavage
Calcium
Complete proteome
Direct protein sequencing
Disulfide bond
Hydrolase
Lipid degradation
Lipid metabolism
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal
Zymogen

Publication

PubMed ID:
3028739 14702039 16541075 15489334 7060561 6349696 19297324