Names & Taxonomy

Uniprot ID:
P03950
Entry Name:
ANGI_HUMAN
Status:
reviewed
Protein Names:
Angiogenin (EC 3.1.27.-) (Ribonuclease 5) (RNase 5)
Gene Names:
ANG RNASE5
Gene Names Primary:
ANG
Organism:
Homo sapiens (Human)

Structure

Length:
147
Sequence:
MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasmic vesicle, secretory vesicle lumen

Function

Function:
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Active Site:
ACT_SITE 37 37 Proton acceptor.; ACT_SITE 138 138 Proton donor.
Gene Ontology Go:
angiogenin-PRI complex
basal lamina
cytoplasmic, membrane-bounded vesicle
extracellular exosome
extracellular region
extracellular space
growth cone
neuronal cell body
nucleolus
nucleus
actin binding
copper ion binding
DNA binding
endonuclease activity
heparin binding
peptide binding
protein homodimerization activity
receptor binding
ribonuclease activity
rRNA binding
actin filament polymerization
activation of phospholipase A2 activity
activation of phospholipase C activity
activation of protein kinase B activity
adherens junction organization
angiogenesis
antibacterial humoral response
antifungal humoral response
cell communication
cell junction assembly
cell migration
cell-cell junction organization
defense response to Gram-positive bacterium
diacylglycerol biosynthetic process
homeostatic process
innate immune response
negative regulation of smooth muscle cell proliferation
negative regulation of translation
nucleic acid phosphodiester bond hydrolysis
oocyte maturation
ovarian follicle development
placenta development
positive regulation of endothelial cell proliferation
positive regulation of phosphorylation
positive regulation of protein secretion
response to hormone
response to hypoxia
response to yeast
RNA phosphodiester bond hydrolysis
rRNA transcription
Gene Ontology Biological Process:
actin filament polymerization
activation of phospholipase A2 activity
activation of phospholipase C activity
activation of protein kinase B activity
adherens junction organization
angiogenesis
antibacterial humoral response
antifungal humoral response
cell-cell junction organization
cell communication
cell junction assembly
cell migration
defense response to Gram-positive bacterium
diacylglycerol biosynthetic process
homeostatic process
innate immune response
negative regulation of smooth muscle cell proliferation
negative regulation of translation
nucleic acid phosphodiester bond hydrolysis
oocyte maturation
ovarian follicle development
placenta development
positive regulation of endothelial cell proliferation
positive regulation of phosphorylation
positive regulation of protein secretion
response to hormone
response to hypoxia
response to yeast
RNA phosphodiester bond hydrolysis
rRNA transcription
Gene Ontology Molecular Function:
actin binding
copper ion binding
DNA binding
endonuclease activity
heparin binding
peptide binding
protein homodimerization activity
receptor binding
ribonuclease activity
rRNA binding
Gene Ontology Cellular Component:
angiogenin-PRI complex
basal lamina
cytoplasmic, membrane-bounded vesicle
extracellular exosome
extracellular region
extracellular space
growth cone
neuronal cell body
nucleolus
nucleus
Keywords:
3D-structure
Amyotrophic lateral sclerosis
Angiogenesis
Complete proteome
Cytoplasmic vesicle
DNA-binding
Developmental protein
Differentiation
Direct protein sequencing
Disease mutation
Disulfide bond
Endonuclease
Hydrolase
Neurodegeneration
Nuclease
Nucleus
Polymorphism
Protein synthesis inhibitor
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal
Stress response
Interacts With:
P35609; P19883; P13489

Publication

PubMed ID:
2866795 11919285 15489334 2866794 2440105 1400510 7945327 9050852 10413501 12051708 19354288 21855800 8159679 9311977 9918722 11468363 11851402 12842050 14756559 9461294 22384259 15557516 16501576 17886298 17900154 18087731 17703939 22292843 25372031