Names & Taxonomy
- Uniprot ID:
- P03886
- Entry Name:
- NU1M_HUMAN
- Status:
- reviewed
- Protein Names:
- NADH-ubiquinone oxidoreductase chain 1 (EC 1.6.5.3) (NADH dehydrogenase subunit 1)
- Gene Names:
- MT-ND1 MTND1 NADH1 ND1
- Gene Names Primary:
- MT-ND1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 318
- Sequence:
- MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSFNLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAGPFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTAYPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
- Gene Encoded:
- Mitochondrion
Function
- Function:
- Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
- Catalytic Activity:
- NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
- Cross Reference Drug Bank:
- DB01189 DB01159 DB00753 DB01028 DB01236
- Gene Ontology Go:
- dendrite
integral component of membrane
mitochondrial inner membrane
mitochondrial membrane
mitochondrial respiratory chain complex I
neuronal cell body
NADH dehydrogenase (ubiquinone) activity
cellular metabolic process
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I assembly
respiratory electron transport chain
response to drug
response to hydroperoxide
response to organic cyclic compound
small molecule metabolic process - Gene Ontology Biological Process:
- cellular metabolic process
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I assembly
respiratory electron transport chain
response to drug
response to hydroperoxide
response to organic cyclic compound
small molecule metabolic process - Gene Ontology Molecular Function:
- NADH dehydrogenase (ubiquinone) activity
- Gene Ontology Cellular Component:
- dendrite
integral component of membrane
mitochondrial inner membrane
mitochondrial membrane
mitochondrial respiratory chain complex I
neuronal cell body - Keywords:
- Alzheimer disease
Amyloidosis
Complete proteome
Diabetes mellitus
Disease mutation
Electron transport
Epilepsy
Leber hereditary optic neuropathy
MELAS syndrome
Membrane
Mitochondrion
Mitochondrion inner membrane
NAD
Neurodegeneration
Oxidoreductase
Polymorphism
Reference proteome
Respiratory chain
Transmembrane
Transmembrane helix
Transport
Ubiquinone - Interacts With:
- P43490