Names & Taxonomy
- Uniprot ID:
- P02795
- Entry Name:
- MT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Metallothionein-2 (MT-2) (Metallothionein-2A) (Metallothionein-II) (MT-II)
- Gene Names:
- MT2A CES1 MT2
- Gene Names Primary:
- MT2A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 61
- Sequence:
- MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGASDKCSCCA
- Proteomes:
- UP000005640
Function
- Function:
- Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
- Cross Reference Drug Bank:
- DB00958 DB00515 DB00526
- Gene Ontology Go:
- cytoplasm
cytosol
nucleus
perinuclear region of cytoplasm
drug binding
zinc ion binding
cellular copper ion homeostasis
cellular response to drug
cellular response to erythropoietin
cellular response to interleukin-3
cellular response to zinc ion
cytokine-mediated signaling pathway
interferon-gamma-mediated signaling pathway
negative regulation of growth
response to metal ion
small molecule metabolic process - Gene Ontology Biological Process:
- cellular copper ion homeostasis
cellular response to drug
cellular response to erythropoietin
cellular response to interleukin-3
cellular response to zinc ion
cytokine-mediated signaling pathway
interferon-gamma-mediated signaling pathway
negative regulation of growth
response to metal ion
small molecule metabolic process - Gene Ontology Molecular Function:
- drug binding
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleus
perinuclear region of cytoplasm - Keywords:
- 3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Metal-binding
Metal-thiolate cluster
Phosphoprotein
Polymorphism
Reference proteome
Zinc - Interacts With:
- Q8TE69; Q13585; Q15139; P58062