Names & Taxonomy

Uniprot ID:
P02795
Entry Name:
MT2_HUMAN
Status:
reviewed
Protein Names:
Metallothionein-2 (MT-2) (Metallothionein-2A) (Metallothionein-II) (MT-II)
Gene Names:
MT2A CES1 MT2
Gene Names Primary:
MT2A
Organism:
Homo sapiens (Human)

Structure

Length:
61
Sequence:
MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGASDKCSCCA
Proteomes:
UP000005640

Function

Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Cross Reference Drug Bank:
DB00958 DB00515 DB00526
Gene Ontology Go:
cytoplasm
cytosol
nucleus
perinuclear region of cytoplasm
drug binding
zinc ion binding
cellular copper ion homeostasis
cellular response to drug
cellular response to erythropoietin
cellular response to interleukin-3
cellular response to zinc ion
cytokine-mediated signaling pathway
interferon-gamma-mediated signaling pathway
negative regulation of growth
response to metal ion
small molecule metabolic process
Gene Ontology Biological Process:
cellular copper ion homeostasis
cellular response to drug
cellular response to erythropoietin
cellular response to interleukin-3
cellular response to zinc ion
cytokine-mediated signaling pathway
interferon-gamma-mediated signaling pathway
negative regulation of growth
response to metal ion
small molecule metabolic process
Gene Ontology Molecular Function:
drug binding
zinc ion binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
nucleus
perinuclear region of cytoplasm
Keywords:
3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Metal-binding
Metal-thiolate cluster
Phosphoprotein
Polymorphism
Reference proteome
Zinc
Interacts With:
Q8TE69; Q13585; Q15139; P58062

Publication

PubMed ID:
913597 7133118 6896577 2780570 1339282 15489334 19413330 24275569 2388267 1593628