Names & Taxonomy
- Uniprot ID:
- P02794
- Entry Name:
- FRIH_HUMAN
- Status:
- reviewed
- Protein Names:
- Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed]
- Gene Names:
- FTH1 FTH FTHL6 OK/SW-cl.84 PIG15
- Gene Names Orf:
- OK/SW-cl.84 PIG15
- Gene Names Primary:
- FTH1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 183
- Sequence:
- MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES
- Proteomes:
- UP000005640
Function
- Function:
- Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
- Catalytic Activity:
- 4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.
- Cross Reference Drug Bank:
- DB00893
- Gene Ontology Go:
- cytosol
extracellular exosome
intracellular ferritin complex
nucleus
ferric iron binding
ferroxidase activity
iron ion binding
cellular iron ion homeostasis
immune response
intracellular sequestering of iron ion
iron ion transport
membrane organization
negative regulation of cell proliferation
negative regulation of fibroblast proliferation
post-Golgi vesicle-mediated transport
receptor-mediated endocytosis
transmembrane transport - Gene Ontology Biological Process:
- cellular iron ion homeostasis
immune response
intracellular sequestering of iron ion
iron ion transport
membrane organization
negative regulation of cell proliferation
negative regulation of fibroblast proliferation
post-Golgi vesicle-mediated transport
receptor-mediated endocytosis
transmembrane transport - Gene Ontology Molecular Function:
- ferric iron binding
ferroxidase activity
iron ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
intracellular ferritin complex
nucleus - Keywords:
- 3D-structure
Acetylation
Complete proteome
Iron
Iron storage
Metal-binding
Oxidoreductase
Phosphoprotein
Reference proteome - Interacts With:
- Q9UER7; P02792; Q2Q067; P04792; P61244