Names & Taxonomy
- Uniprot ID:
- P02786
- Entry Name:
- TFR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]
- Gene Names:
- TFRC
- Gene Names Primary:
- TFRC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 760
- Sequence:
- MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPKRCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRKQNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
- Cross Reference Drug Bank:
- DB05260
- Gene Ontology Go:
- basolateral plasma membrane
blood microparticle
cell surface
coated pit
cytoplasmic, membrane-bounded vesicle
endosome
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
extracellular vesicle
HFE-transferrin receptor complex
integral component of plasma membrane
intracellular membrane-bounded organelle
melanosome
membrane
mitochondrion
perinuclear region of cytoplasm
plasma membrane
recycling endosome
recycling endosome membrane
double-stranded RNA binding
glycoprotein binding
identical protein binding
poly(A) RNA binding
protein homodimerization activity
transferrin receptor activity
transferrin transmembrane transporter activity
virus receptor activity
acute-phase response
aging
cellular iron ion homeostasis
cellular response to drug
iron ion import
osteoclast differentiation
positive regulation of bone resorption
response to copper ion
response to hypoxia
response to iron ion
response to manganese ion
response to nutrient
response to retinoic acid
transferrin transport
transmembrane transport - Gene Ontology Biological Process:
- acute-phase response
aging
cellular iron ion homeostasis
cellular response to drug
iron ion import
osteoclast differentiation
positive regulation of bone resorption
response to copper ion
response to hypoxia
response to iron ion
response to manganese ion
response to nutrient
response to retinoic acid
transferrin transport
transmembrane transport - Gene Ontology Molecular Function:
- double-stranded RNA binding
glycoprotein binding
identical protein binding
poly(A) RNA binding
protein homodimerization activity
transferrin receptor activity
transferrin transmembrane transporter activity
virus receptor activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
blood microparticle
cell surface
coated pit
cytoplasmic, membrane-bounded vesicle
endosome
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
extracellular vesicle
HFE-transferrin receptor complex
integral component of plasma membrane
intracellular membrane-bounded organelle
melanosome
membrane
mitochondrion
perinuclear region of cytoplasm
plasma membrane
recycling endosome
recycling endosome membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Endocytosis
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Secreted
Signal-anchor
Transmembrane
Transmembrane helix - Interacts With:
- Itself; P02768; Q30201; O43765; Q9P0V3
Publication
- PubMed ID:
- 6090955 6094009 9358047 15489334 2229063 1871153 7864799 1380674 3568132 3582362 2507316 2327986 2298808 1421756 1421757 8408022 7780197 8631371 10377239 11800564 16325581 16335952 15592455 17081065 17287727 18669648 18268337 19159218 19349973 19690332 20068231 21269460 24275569 25944712 9782058 10531064 11702220