Names & Taxonomy

Uniprot ID:
P02763
Entry Name:
A1AG1_HUMAN
Status:
reviewed
Protein Names:
Alpha-1-acid glycoprotein 1 (AGP 1) (Orosomucoid-1) (OMD 1)
Gene Names:
ORM1 AGP1
Gene Names Primary:
ORM1
Organism:
Homo sapiens (Human)

Structure

Length:
201
Sequence:
MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDQITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQDQCIYNTTYLNVQRENGTISRYVGGQEHFAHLLILRDTKTYMLAFDVNDEKNWGLSVYADKPETTKEQLGEFYEALDCLRIPKSDVVYTDWKKDKCEPLEKQHEKERKQEEGES
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Cross Reference Drug Bank:
DB05812 DB01418 DB01426 DB00802 DB00321 DB00543 DB01429 DB01156 DB08907 DB00482 DB00477 DB01151 DB00280 DB00590 DB01142 DB00530 DB00472 DB00317 DB00619 DB00458 DB08820 DB00934 DB08893 DB00731 DB00540 DB00334 DB00497 DB01359 DB00454 DB00946 DB08860 DB00457 DB00571 DB00908 DB08931 DB01232 DB00864 DB00706 DB05521 DB01041 DB00656 DB08867 DB05294 DB08881 DB08828 DB00682
Gene Ontology Go:
blood microparticle
extracellular exosome
extracellular region
extracellular space
acute-phase response
inflammatory response
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
regulation of immune system process
transport
Gene Ontology Biological Process:
acute-phase response
inflammatory response
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
regulation of immune system process
transport
Gene Ontology Cellular Component:
blood microparticle
extracellular exosome
extracellular region
extracellular space
Keywords:
3D-structure
Acute phase
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Polymorphism
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal
Transport
Interacts With:
P05121

Publication

PubMed ID:
2822385 3770479 2409529 14702039 15164053 15489334 4711474 4561179 4603214 1567356 12754519 15253437 15084671 14760718 16335952 17008009 16740002 17321687 19159218 19838169 22171320 18823996 9050929