Names & Taxonomy

Uniprot ID:
P02743
Entry Name:
SAMP_HUMAN
Status:
reviewed
Protein Names:
Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]
Gene Names:
APCS PTX2
Gene Names Primary:
APCS
Organism:
Homo sapiens (Human)

Structure

Length:
223
Sequence:
MNKPLLWISVLTSLLEAFAHTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 2 calcium ions per subunit.;
Gene Ontology Go:
blood microparticle
extracellular exosome
extracellular region
extracellular space
nucleus
calcium ion binding
carbohydrate binding
complement component C1q binding
unfolded protein binding
virion binding
acute-phase response
cellular protein metabolic process
chaperone-mediated protein complex assembly
innate immune response
negative regulation by host of viral exo-alpha-sialidase activity
negative regulation by host of viral glycoprotein metabolic process
negative regulation of acute inflammatory response
negative regulation of exo-alpha-sialidase activity
negative regulation of glycoprotein metabolic process
negative regulation of monocyte differentiation
negative regulation of viral entry into host cell
negative regulation of viral process
negative regulation of wound healing
protein folding
Gene Ontology Biological Process:
acute-phase response
cellular protein metabolic process
chaperone-mediated protein complex assembly
innate immune response
negative regulation by host of viral exo-alpha-sialidase activity
negative regulation by host of viral glycoprotein metabolic process
negative regulation of acute inflammatory response
negative regulation of exo-alpha-sialidase activity
negative regulation of glycoprotein metabolic process
negative regulation of monocyte differentiation
negative regulation of viral entry into host cell
negative regulation of viral process
negative regulation of wound healing
protein folding
Gene Ontology Molecular Function:
calcium ion binding
carbohydrate binding
complement component C1q binding
unfolded protein binding
virion binding
Gene Ontology Cellular Component:
blood microparticle
extracellular exosome
extracellular region
extracellular space
nucleus
Keywords:
3D-structure
Amyloid
Calcium
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Lectin
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal

Publication

PubMed ID:
2987268 3029048 16710414 15489334 4055725 81686 8202534 15174148 16335952 19159218 21269460 24275569 8114934 9217261 16959974