Names & Taxonomy
- Uniprot ID:
- P02708
- Entry Name:
- ACHA_HUMAN
- Status:
- reviewed
- Protein Names:
- Acetylcholine receptor subunit alpha
- Gene Names:
- CHRNA1 ACHRA CHNRA
- Gene Names Primary:
- CHRNA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 482
- Sequence:
- MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Function
- Function:
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
- Cross Reference Drug Bank:
- DB00674
- Gene Ontology Go:
- acetylcholine-gated channel complex
cell junction
cell surface
neuromuscular junction
plasma membrane
postsynaptic membrane
acetylcholine binding
acetylcholine receptor activity
acetylcholine-activated cation-selective channel activity
ion channel activity
chemical synaptic transmission, postsynaptic
muscle cell cellular homeostasis
musculoskeletal movement
neuromuscular junction development
neuromuscular process
neuromuscular synaptic transmission
neuron cellular homeostasis
neuronal action potential
regulation of membrane potential
response to nicotine
signal transduction
skeletal muscle contraction
skeletal muscle tissue growth
synaptic transmission
synaptic transmission, cholinergic
transport - Gene Ontology Biological Process:
- chemical synaptic transmission, postsynaptic
muscle cell cellular homeostasis
musculoskeletal movement
neuromuscular junction development
neuromuscular process
neuromuscular synaptic transmission
neuronal action potential
neuron cellular homeostasis
regulation of membrane potential
response to nicotine
signal transduction
skeletal muscle contraction
skeletal muscle tissue growth
synaptic transmission
synaptic transmission, cholinergic
transport - Gene Ontology Molecular Function:
- acetylcholine-activated cation-selective channel activity
acetylcholine binding
acetylcholine receptor activity
ion channel activity - Gene Ontology Cellular Component:
- acetylcholine-gated channel complex
cell junction
cell surface
neuromuscular junction
plasma membrane
postsynaptic membrane - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Congenital myasthenic syndrome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport