Names & Taxonomy
- Uniprot ID:
- P02679
- Entry Name:
- FIBG_HUMAN
- Status:
- reviewed
- Protein Names:
- Fibrinogen gamma chain
- Gene Names:
- FGG PRO2061
- Gene Names Orf:
- PRO2061
- Gene Names Primary:
- FGG
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 453
- Sequence:
- MSWSLHPRNLILYFYALLFLSSTCVAYVATRDNCCILDERFGSYCPTTCGIADFLSTYQTKVDKDLQSLEDILHQVENKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKSRKMLEEIMKYEASILTHDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLTIGEGQQHHLGGAKQVRPEHPAETEYDSLYPEDDL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
- Cross Reference Drug Bank:
- DB00364
- Gene Ontology Go:
- blood microparticle
cell cortex
cell surface
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
fibrinogen complex
plasma membrane
platelet alpha granule
platelet alpha granule lumen
cell adhesion molecule binding
metal ion binding
receptor binding
structural molecule activity
blood coagulation
blood coagulation, fibrin clot formation
cell-matrix adhesion
cellular protein complex assembly
extracellular matrix organization
fibrinolysis
negative regulation of endothelial cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
plasminogen activation
platelet activation
platelet aggregation
platelet degranulation
positive regulation of ERK1 and ERK2 cascade
positive regulation of exocytosis
positive regulation of heterotypic cell-cell adhesion
positive regulation of peptide hormone secretion
positive regulation of protein secretion
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of vasoconstriction
protein polymerization
protein secretion
response to calcium ion
signal transduction - Gene Ontology Biological Process:
- blood coagulation
blood coagulation, fibrin clot formation
cell-matrix adhesion
cellular protein complex assembly
extracellular matrix organization
fibrinolysis
negative regulation of endothelial cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
plasminogen activation
platelet activation
platelet aggregation
platelet degranulation
positive regulation of ERK1 and ERK2 cascade
positive regulation of exocytosis
positive regulation of heterotypic cell-cell adhesion
positive regulation of peptide hormone secretion
positive regulation of protein secretion
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of vasoconstriction
protein polymerization
protein secretion
response to calcium ion
signal transduction - Gene Ontology Molecular Function:
- cell adhesion molecule binding
metal ion binding
receptor binding
structural molecule activity - Gene Ontology Cellular Component:
- blood microparticle
cell cortex
cell surface
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
fibrinogen complex
plasma membrane
platelet alpha granule
platelet alpha granule lumen - Keywords:
- 3D-structure
Alternative splicing
Blood coagulation
Calcium
Coiled coil
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hemostasis
Isopeptide bond
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Signal
Sulfation
Publication
- PubMed ID:
- 6688357 2990550 14702039 15489334 8509453 1685103 6689067 6092346 7654933 7306501 6575689 936108 6860649 1892842 11307817 6383194 6592597 6451630 6326808 6325435 3160702 6933547 14760718 16335952 16263699 18780401 19159218 19139490 2143188 21269460 24275569 26091039 9016719 9207064 9333233 9628725 10074346 19296670 2496144 1421174 2257302 2328317 8400260 2971046 2819242 3708159 7841300 8080993 2738036 2971042 1455400 1733971 8470043 3337908 2071611 3563970 2976995 11435303 10391209 11986213 15632207 25427968