Names & Taxonomy
- Uniprot ID:
- P02458
- Entry Name:
- CO2A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin]
- Gene Names:
- COL2A1
- Gene Names Primary:
- COL2A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1487
- Sequence:
- MIRLGAPQTLVLLTLLVAAVLRCQGQDVQEAGSCVQDGQRYNDKDVWKPEPCRICVCDTGTVLCDDIICEDVKDCLSPEIPFGECCPICPTDLATASGQPGPKGQKGEPGDIKDIVGPKGPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGNPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREKGPDPLQYMRADQAAGGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGDYWIDPNQGCTLDAMKVFCNMETGETCVYPNPANVPKKNWWSSKSKEKKHIWFGETINGGFHFSYGDDNLAPNTANVQMTFLRLLSTEGSQNITYHCKNSIAYLDEAAGNLKKALLIQGSNDVEIRAEGNSRFTYTALKDGCTKHTGKWGKTVIEYRSQKTSRLPIIDIAPMDIGGPEQEFGVDIGPVCFL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
- Cross Reference Drug Bank:
- DB00048
- Gene Ontology Go:
- basement membrane
collagen type II trimer
endoplasmic reticulum lumen
extracellular matrix
extracellular region
extracellular space
extracellular matrix structural constituent conferring tensile strength
identical protein binding
metal ion binding
platelet-derived growth factor binding
axon guidance
cartilage condensation
cartilage development
cartilage development involved in endochondral bone morphogenesis
cellular response to BMP stimulus
central nervous system development
chondrocyte differentiation
collagen catabolic process
collagen fibril organization
embryonic skeletal joint morphogenesis
endochondral ossification
extracellular matrix disassembly
extracellular matrix organization
heart morphogenesis
inner ear morphogenesis
limb bud formation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
notochord development
otic vesicle development
palate development
proteoglycan metabolic process
regulation of gene expression
regulation of immune response
sensory perception of sound
skeletal system development
tissue homeostasis
visual perception - Gene Ontology Biological Process:
- axon guidance
cartilage condensation
cartilage development
cartilage development involved in endochondral bone morphogenesis
cellular response to BMP stimulus
central nervous system development
chondrocyte differentiation
collagen catabolic process
collagen fibril organization
embryonic skeletal joint morphogenesis
endochondral ossification
extracellular matrix disassembly
extracellular matrix organization
heart morphogenesis
inner ear morphogenesis
limb bud formation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
notochord development
otic vesicle development
palate development
proteoglycan metabolic process
regulation of gene expression
regulation of immune response
sensory perception of sound
skeletal system development
tissue homeostasis
visual perception - Gene Ontology Molecular Function:
- extracellular matrix structural constituent conferring tensile strength
identical protein binding
metal ion binding
platelet-derived growth factor binding - Gene Ontology Cellular Component:
- basement membrane
collagen type II trimer
endoplasmic reticulum lumen
extracellular matrix
extracellular region
extracellular space - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cataract
Collagen
Complete proteome
Deafness
Direct protein sequencing
Disease mutation
Disulfide bond
Dwarfism
Extracellular matrix
Glycoprotein
Hydroxylation
Metal-binding
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Stickler syndrome
Publication
- PubMed ID:
- 2587267 8948452 16541075 15489334 2803268 2714801 2081599 3021582 1637314 2355003 1999183 8660302 8529631 7847372 2987845 2753125 3857598 1429602 1905723 2543071 2339128 2825137 3840017 3800925 6320112 3002437 9354468 15466413 26183434 2010058 9101290 2572591 1975693 1985108 1374906 8317498 8507190 8486375 8244341 8325895 8423604 7977371 7874117 8019561 7757081 7757086 7829510 7550321 8723098 8863156 9800905 9711874 11007540 10678662 10797431 10745044 11746045 12205109 15054848 15316962 14729840 15643621 16088915 15671297 15930420 16752401 17994563 17394019 18553548 18272325 17721977 19764028 20513134 21671384 21922596