Names & Taxonomy
- Uniprot ID:
- P01589
- Entry Name:
- IL2RA_HUMAN
- Status:
- reviewed
- Protein Names:
- Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25)
- Gene Names:
- IL2RA
- Gene Names Primary:
- IL2RA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 272
- Sequence:
- MDSYLLMWGLLTFIMVPGCQAELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQASPEGRPESETSCLVTTTDFQIQTEMAATMETSIFTTEYQVAVAGCVFLLISVLLLSGLTWQRRQRKSRRTI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
- Cross Reference Drug Bank:
- DB00041 DB00074 DB00111 DB00004
- Gene Ontology Go:
- external side of plasma membrane
integral component of membrane
intracellular
plasma membrane
drug binding
interleukin-2 binding
interleukin-2 receptor activity
activation of MAPKK activity
activation-induced cell death of T cells
apoptotic process
axon guidance
cell proliferation
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
immune response
inflammatory response
inflammatory response to antigenic stimulus
innate immune response
insulin receptor signaling pathway
MAPK cascade
negative regulation of defense response to virus
negative regulation of immune response
negative regulation of inflammatory response
negative regulation of T cell proliferation
neurotrophin TRK receptor signaling pathway
Notch signaling pathway
positive regulation of activated T cell proliferation
positive regulation of T cell differentiation
Ras protein signal transduction
regulation of T cell homeostatic proliferation
regulation of T cell tolerance induction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation-induced cell death of T cells
activation of MAPKK activity
apoptotic process
axon guidance
cell proliferation
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
immune response
inflammatory response
inflammatory response to antigenic stimulus
innate immune response
insulin receptor signaling pathway
MAPK cascade
negative regulation of defense response to virus
negative regulation of immune response
negative regulation of inflammatory response
negative regulation of T cell proliferation
neurotrophin TRK receptor signaling pathway
Notch signaling pathway
positive regulation of activated T cell proliferation
positive regulation of T cell differentiation
Ras protein signal transduction
regulation of T cell homeostatic proliferation
regulation of T cell tolerance induction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- drug binding
interleukin-2 binding
interleukin-2 receptor activity - Gene Ontology Cellular Component:
- external side of plasma membrane
integral component of membrane
intracellular
plasma membrane - Keywords:
- 3D-structure
Complete proteome
Diabetes mellitus
Disease mutation
Disulfide bond
Glycoprotein
Immunity
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Sushi
Transmembrane
Transmembrane helix