Names & Taxonomy

Uniprot ID:
P01374
Entry Name:
TNFB_HUMAN
Status:
reviewed
Protein Names:
Lymphotoxin-alpha (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1)
Gene Names:
LTA TNFB TNFSF1
Gene Names Primary:
LTA
Organism:
Homo sapiens (Human)

Structure

Length:
205
Sequence:
MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated.

Function

Function:
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
Cross Reference Drug Bank:
DB00005
Gene Ontology Go:
extracellular space
plasma membrane
receptor binding
apoptotic process
cell-cell signaling
defense response to Gram-positive bacterium
humoral immune response
lymph node development
negative regulation of fibroblast proliferation
negative regulation of growth of symbiont in host
positive regulation of apoptotic process
positive regulation of chronic inflammatory response to antigenic stimulus
positive regulation of glial cell proliferation
positive regulation of humoral immune response mediated by circulating immunoglobulin
positive regulation of interferon-gamma production
response to drug
response to hypoxia
response to lipopolysaccharide
response to nutrient
signal transduction
tumor necrosis factor-mediated signaling pathway
Gene Ontology Biological Process:
apoptotic process
cell-cell signaling
defense response to Gram-positive bacterium
humoral immune response
lymph node development
negative regulation of fibroblast proliferation
negative regulation of growth of symbiont in host
positive regulation of apoptotic process
positive regulation of chronic inflammatory response to antigenic stimulus
positive regulation of glial cell proliferation
positive regulation of humoral immune response mediated by circulating immunoglobulin
positive regulation of interferon-gamma production
response to drug
response to hypoxia
response to lipopolysaccharide
response to nutrient
signal transduction
tumor necrosis factor-mediated signaling pathway
Gene Ontology Molecular Function:
receptor binding
Gene Ontology Cellular Component:
extracellular space
plasma membrane
Keywords:
3D-structure
Complete proteome
Cytokine
Direct protein sequencing
Glycoprotein
Membrane
Polymorphism
Reference proteome
Secreted
Signal

Publication

PubMed ID:
3555974 3001109 3536896 6334807 1353024 8499947 10202016 14656967 15489334 1451807 1733919 8387891 1670638 1671667 12746914 17353895