Names & Taxonomy
- Uniprot ID:
- P01189
- Entry Name:
- COLI_HUMAN
- Status:
- reviewed
- Protein Names:
- Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH); Beta-endorphin; Met-enkephalin]
- Gene Names:
- POMC
- Gene Names Primary:
- POMC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 267
- Sequence:
- MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGGPEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- ACTH stimulates the adrenal glands to release cortisol.; MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.; Beta-endorphin and Met-enkephalin are endogenous opiates.
- Cross Reference Drug Bank:
- DB00836
- Gene Ontology Go:
- cytoplasm
extracellular region
extracellular space
peroxisomal matrix
secretory granule
secretory granule lumen
G-protein coupled receptor binding
hormone activity
receptor binding
type 1 melanocortin receptor binding
type 3 melanocortin receptor binding
type 4 melanocortin receptor binding
cell-cell signaling
cellular pigmentation
cellular protein metabolic process
generation of precursor metabolites and energy
glucose homeostasis
negative regulation of tumor necrosis factor production
neuropeptide signaling pathway
peptide hormone processing
positive regulation of transcription from RNA polymerase II promoter
regulation of appetite
regulation of blood pressure
regulation of corticosterone secretion
regulation of glycogen metabolic process
signal transduction - Gene Ontology Biological Process:
- cell-cell signaling
cellular pigmentation
cellular protein metabolic process
generation of precursor metabolites and energy
glucose homeostasis
negative regulation of tumor necrosis factor production
neuropeptide signaling pathway
peptide hormone processing
positive regulation of transcription from RNA polymerase II promoter
regulation of appetite
regulation of blood pressure
regulation of corticosterone secretion
regulation of glycogen metabolic process
signal transduction - Gene Ontology Molecular Function:
- G-protein coupled receptor binding
hormone activity
receptor binding
type 1 melanocortin receptor binding
type 3 melanocortin receptor binding
type 4 melanocortin receptor binding - Gene Ontology Cellular Component:
- cytoplasm
extracellular region
extracellular space
peroxisomal matrix
secretory granule
secretory granule lumen - Keywords:
- Acetylation
Amidation
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disulfide bond
Endorphin
Glycoprotein
Hormone
Obesity
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Signal