Names & Taxonomy

Uniprot ID:
P01178
Entry Name:
NEU1_HUMAN
Status:
reviewed
Protein Names:
Oxytocin-neurophysin 1 (OT-NPI) [Cleaved into: Oxytocin (Ocytocin); Neurophysin 1]
Gene Names:
OXT OT
Gene Names Primary:
OXT
Organism:
Homo sapiens (Human)

Structure

Length:
125
Sequence:
MAGPSLACCLLGLLALTSACYIQNCPLGGKRAAPDLDVRKCLPCGPGGKGRCFGPNICCAEELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAVLGLCCSPDGCHADPACDAEATFSQR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Neurophysin 1 specifically binds oxytocin.; Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
Cross Reference Drug Bank:
DB00107
Gene Ontology Go:
cytosol
extracellular region
extracellular space
secretory granule
terminal bouton
drinking behavior
eating behavior
female pregnancy
grooming behavior
heart development
hyperosmotic salinity response
male mating behavior
maternal aggressive behavior
maternal behavior
memory
negative regulation of blood pressure
negative regulation of gastric acid secretion
negative regulation of urine volume
positive regulation of blood pressure
positive regulation of cytosolic calcium ion concentration
positive regulation of female receptivity
positive regulation of hindgut contraction
positive regulation of norepinephrine secretion
positive regulation of ossification
positive regulation of penile erection
positive regulation of prostaglandin secretion
positive regulation of renal sodium excretion
positive regulation of synapse assembly
positive regulation of synaptic transmission
positive regulation of uterine smooth muscle contraction
regulation of heart rate
regulation of sensory perception of pain
response to activity
response to amphetamine
response to cAMP
response to cocaine
response to electrical stimulus
response to estradiol
response to ether
response to food
response to glucocorticoid
response to peptide hormone
response to progesterone
response to prostaglandin E
response to retinoic acid
response to sucrose
signal transduction
sleep
social behavior
sperm ejaculation
Gene Ontology Biological Process:
drinking behavior
eating behavior
female pregnancy
grooming behavior
heart development
hyperosmotic salinity response
male mating behavior
maternal aggressive behavior
maternal behavior
memory
negative regulation of blood pressure
negative regulation of gastric acid secretion
negative regulation of urine volume
positive regulation of blood pressure
positive regulation of cytosolic calcium ion concentration
positive regulation of female receptivity
positive regulation of hindgut contraction
positive regulation of norepinephrine secretion
positive regulation of ossification
positive regulation of penile erection
positive regulation of prostaglandin secretion
positive regulation of renal sodium excretion
positive regulation of synapse assembly
positive regulation of synaptic transmission
positive regulation of uterine smooth muscle contraction
regulation of heart rate
regulation of sensory perception of pain
response to activity
response to amphetamine
response to cAMP
response to cocaine
response to electrical stimulus
response to estradiol
response to ether
response to food
response to glucocorticoid
response to peptide hormone
response to progesterone
response to prostaglandin E
response to retinoic acid
response to sucrose
signal transduction
sleep
social behavior
sperm ejaculation
Gene Ontology Cellular Component:
cytosol
extracellular region
extracellular space
secretory granule
terminal bouton
Keywords:
Amidation
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disulfide bond
Hormone
Pharmaceutical
Reference proteome
Secreted
Signal
Interacts With:
P16333

Publication

PubMed ID:
3768139 2991279 11780052 15489334 2249637 4065330 6574452 7262323 13591312