Names & Taxonomy

Uniprot ID:
P01100
Entry Name:
FOS_HUMAN
Status:
reviewed
Protein Names:
Proto-oncogene c-Fos (Cellular oncogene fos) (G0/G1 switch regulatory protein 7)
Gene Names:
FOS G0S7
Gene Names Primary:
FOS
Organism:
Homo sapiens (Human)

Structure

Length:
380
Sequence:
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.

Function

Function:
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Cross Reference Drug Bank:
DB08813 DB00852
Gene Ontology Go:
cytosol
endoplasmic reticulum
membrane
neuron projection
nucleoplasm
nucleus
transcription factor complex
chromatin binding
R-SMAD binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
aging
cellular response to calcium ion
cellular response to extracellular stimulus
cellular response to hormone stimulus
cellular response to reactive oxygen species
conditioned taste aversion
DNA methylation
Fc-epsilon receptor signaling pathway
female pregnancy
inflammatory response
innate immune response
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
nervous system development
positive regulation of osteoclast differentiation
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of sequence-specific DNA binding transcription factor activity
regulation of transcription from RNA polymerase II promoter
response to cAMP
response to cold
response to corticosterone
response to cytokine
response to drug
response to gravity
response to immobilization stress
response to light stimulus
response to lipopolysaccharide
response to muscle stretch
response to progesterone
response to toxic substance
skeletal muscle cell differentiation
sleep
SMAD protein signal transduction
stress-activated MAPK cascade
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
Gene Ontology Biological Process:
aging
cellular response to calcium ion
cellular response to extracellular stimulus
cellular response to hormone stimulus
cellular response to reactive oxygen species
conditioned taste aversion
DNA methylation
Fc-epsilon receptor signaling pathway
female pregnancy
inflammatory response
innate immune response
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
nervous system development
positive regulation of osteoclast differentiation
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of sequence-specific DNA binding transcription factor activity
regulation of transcription from RNA polymerase II promoter
response to cAMP
response to cold
response to corticosterone
response to cytokine
response to drug
response to gravity
response to immobilization stress
response to light stimulus
response to lipopolysaccharide
response to muscle stretch
response to progesterone
response to toxic substance
skeletal muscle cell differentiation
sleep
SMAD protein signal transduction
stress-activated MAPK cascade
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
Gene Ontology Molecular Function:
chromatin binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
R-SMAD binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding
Gene Ontology Cellular Component:
cytosol
endoplasmic reticulum
membrane
neuron projection
nucleoplasm
nucleus
transcription factor complex
Keywords:
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Endoplasmic reticulum
Isopeptide bond
Nucleus
Phosphoprotein
Proto-oncogene
Reference proteome
Ubl conjugation
Interacts With:
P05067; P15336; P18848; P17544; P10909; Q9BT78; P05412; P17275; P17535; P56671; O14974; P42224; P52736

Publication

PubMed ID:
6574479 14702039 12508121 15489334 1658710 2516827 2511004 7588633 9732876 12134156 16055710 17203973 17709345 17160021 19690332 22105363 25218447 25772364 7816143