Names & Taxonomy
- Uniprot ID:
- P01031
- Entry Name:
- CO5_HUMAN
- Status:
- reviewed
- Protein Names:
- Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain]
- Gene Names:
- C5 CPAMD4
- Gene Names Primary:
- C5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1676
- Sequence:
- MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
- Cross Reference Drug Bank:
- DB01257 DB00028
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
membrane attack complex
chemokine activity
endopeptidase inhibitor activity
receptor binding
activation of MAPK activity
cell chemotaxis
cell surface receptor signaling pathway
chemotaxis
complement activation
complement activation, alternative pathway
complement activation, classical pathway
cytolysis
G-protein coupled receptor signaling pathway
in utero embryonic development
inflammatory response
innate immune response
mitophagy in response to mitochondrial depolarization
negative regulation of macrophage chemotaxis
positive regulation of angiogenesis
positive regulation of chemokine secretion
positive regulation of vascular endothelial growth factor production
regulation of complement activation
response to stress - Gene Ontology Biological Process:
- activation of MAPK activity
cell chemotaxis
cell surface receptor signaling pathway
chemotaxis
complement activation
complement activation, alternative pathway
complement activation, classical pathway
cytolysis
G-protein coupled receptor signaling pathway
inflammatory response
innate immune response
in utero embryonic development
mitophagy in response to mitochondrial depolarization
negative regulation of macrophage chemotaxis
positive regulation of angiogenesis
positive regulation of chemokine secretion
positive regulation of vascular endothelial growth factor production
regulation of complement activation
response to stress - Gene Ontology Molecular Function:
- chemokine activity
endopeptidase inhibitor activity
receptor binding - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space
membrane attack complex - Keywords:
- 3D-structure
Cleavage on pair of basic residues
Complement alternate pathway
Complement pathway
Complete proteome
Cytolysis
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunity
Inflammatory response
Innate immunity
Membrane attack complex
Polymorphism
Reference proteome
Secreted
Signal - Interacts With:
- Q91132; Q96BA8