Names & Taxonomy

Uniprot ID:
P01008
Entry Name:
ANT3_HUMAN
Status:
reviewed
Protein Names:
Antithrombin-III (ATIII) (Serpin C1)
Gene Names:
SERPINC1 AT3 PRO0309
Gene Names Orf:
PRO0309
Gene Names Primary:
SERPINC1
Organism:
Homo sapiens (Human)

Structure

Length:
464
Sequence:
MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted, extracellular space.

Function

Function:
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
Cross Reference Drug Bank:
DB00407 DB06779 DB01225 DB00569 DB01109 DB08813 DB06271 DB06822
Gene Ontology Go:
blood microparticle
extracellular exosome
extracellular region
extracellular space
plasma membrane
heparin binding
protease binding
serine-type endopeptidase inhibitor activity
blood coagulation
negative regulation of endopeptidase activity
negative regulation of inflammatory response
regulation of blood coagulation, intrinsic pathway
response to nutrient
Gene Ontology Biological Process:
blood coagulation
negative regulation of endopeptidase activity
negative regulation of inflammatory response
regulation of blood coagulation, intrinsic pathway
response to nutrient
Gene Ontology Molecular Function:
heparin binding
protease binding
serine-type endopeptidase inhibitor activity
Gene Ontology Cellular Component:
blood microparticle
extracellular exosome
extracellular region
extracellular space
plasma membrane
Keywords:
3D-structure
Blood coagulation
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hemostasis
Heparin-binding
Phosphoprotein
Polymorphism
Protease inhibitor
Reference proteome
Secreted
Serine protease inhibitor
Signal
Thrombophilia

Publication

PubMed ID:
6298709 6572945 8476848 14702039 16710414 6305982 3191114 7734359 7238875 6693405 15084671 14760718 15853774 16335952 16263699 19159218 19838169 21269460 24275569 26091039 8087553 7656006 9067613 9761669 2126464 8236149 7749926 8664906 9031473 6582486 3080419 3805013 3179438 3162733 2781509 2365065 1977621 2229057 2013320 1906811 1555650 1547341 8443391 8486379 7981186 7959685 8274732 7994035 7989582 7878627 7832187 9157604 9845533 9759613 10361121 10997988 11794707 11713457 12353073 12595305 12894857 15164384 16908819 23910795