Names & Taxonomy

Uniprot ID:
P00915
Entry Name:
CAH1_HUMAN
Status:
reviewed
Protein Names:
Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase B) (CAB) (Carbonic anhydrase I) (CA-I)
Gene Names:
CA1
Gene Names Primary:
CA1
Organism:
Homo sapiens (Human)

Structure

Length:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.
Catalytic Activity:
H(2)CO(3) = CO(2) + H(2)O.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=4.0 mM for CO(2)
Enzyme Regulation:
ENZYME REGULATION: Activated by histamine, imidazole, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide, benzenesulfonamide and derivatives (4-carboxyethylbenzene-sulfonamide, 4-carboxyethylbenzene-sulfonamide ethyl ester, 4-(acetyl-2-aminoethyl)benzene-sulfonamide, 4-aminoethylbenzene-sulfonamide), and 'prong inhibitors' BR15, BR17, BR22 and BR30. Activated by a short exposition to Foscarnet (phosphonoformate trisodium salt), but inhibited by a long one. Esterase activity weakly reduced by cyanamide.
Active Site:
ACT_SITE 65 65 Proton acceptor.
Cross Reference Drug Bank:
DB00819 DB00381 DB00436 DB00562 DB01194 DB00880 DB00606 DB01119 DB01144 DB00869 DB01031 DB00999 DB00774 DB00703 DB00423 DB00232 DB01325 DB01021 DB00909
Gene Ontology Go:
cytosol
extracellular exosome
arylesterase activity
carbonate dehydratase activity
hydro-lyase activity
zinc ion binding
bicarbonate transport
one-carbon metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
bicarbonate transport
one-carbon metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
arylesterase activity
carbonate dehydratase activity
hydro-lyase activity
zinc ion binding
Gene Ontology Cellular Component:
cytosol
extracellular exosome
Keywords:
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Lyase
Metal-binding
Polymorphism
Reference proteome
Zinc
Interacts With:
Q12800

Publication

PubMed ID:
3104879 2121614 15489334 4217196 4625868 4632246 4207120 10550681 16807956 16686544 17127057 19186056 19206230 18618712 21269460 24275569 4622589 804171 6430186 15299369 8057362 7932756 12009884 16870440 16506782 17314045 17407288 6781336 7866410