Names & Taxonomy
- Uniprot ID:
- P00813
- Entry Name:
- ADA_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)
- Gene Names:
- ADA ADA1
- Gene Names Primary:
- ADA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 363
- Sequence:
- MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen
Function
- Function:
- Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
- Catalytic Activity:
- Adenosine + H(2)O = inosine + NH(3).
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 217 217 Proton donor.
- Cross Reference Drug Bank:
- DB00640 DB00975 DB00974 DB01280 DB00552 DB00277 DB00194
- Gene Ontology Go:
- cell junction
cell surface
cytoplasm
cytoplasmic membrane-bounded vesicle lumen
cytosol
dendrite cytoplasm
external side of plasma membrane
extracellular space
lysosome
membrane
neuronal cell body
plasma membrane
adenosine deaminase activity
purine nucleoside binding
zinc ion binding
adenosine catabolic process
aging
dATP catabolic process
deoxyadenosine catabolic process
embryonic digestive tract development
germinal center B cell differentiation
histamine secretion
hypoxanthine salvage
inosine biosynthetic process
liver development
lung alveolus development
negative regulation of adenosine receptor signaling pathway
negative regulation of circadian sleep/wake cycle, non-REM sleep
negative regulation of inflammatory response
negative regulation of leukocyte migration
negative regulation of mature B cell apoptotic process
negative regulation of mucus secretion
negative regulation of penile erection
negative regulation of thymocyte apoptotic process
nucleobase-containing small molecule metabolic process
Peyer's patch development
placenta development
positive regulation of alpha-beta T cell differentiation
positive regulation of B cell proliferation
positive regulation of calcium-mediated signaling
positive regulation of germinal center formation
positive regulation of heart rate
positive regulation of smooth muscle contraction
positive regulation of T cell differentiation in thymus
positive regulation of T cell receptor signaling pathway
purine nucleobase metabolic process
purine nucleotide salvage
purine ribonucleoside monophosphate biosynthetic process
purine-containing compound salvage
regulation of cell-cell adhesion mediated by integrin
response to drug
response to hydrogen peroxide
response to hypoxia
response to morphine
response to vitamin E
small molecule metabolic process
T cell activation
trophectodermal cell differentiation
xanthine biosynthetic process - Gene Ontology Biological Process:
- adenosine catabolic process
aging
dATP catabolic process
deoxyadenosine catabolic process
embryonic digestive tract development
germinal center B cell differentiation
histamine secretion
hypoxanthine salvage
inosine biosynthetic process
liver development
lung alveolus development
negative regulation of adenosine receptor signaling pathway
negative regulation of circadian sleep/wake cycle, non-REM sleep
negative regulation of inflammatory response
negative regulation of leukocyte migration
negative regulation of mature B cell apoptotic process
negative regulation of mucus secretion
negative regulation of penile erection
negative regulation of thymocyte apoptotic process
nucleobase-containing small molecule metabolic process
Peyer's patch development
placenta development
positive regulation of alpha-beta T cell differentiation
positive regulation of B cell proliferation
positive regulation of calcium-mediated signaling
positive regulation of germinal center formation
positive regulation of heart rate
positive regulation of smooth muscle contraction
positive regulation of T cell differentiation in thymus
positive regulation of T cell receptor signaling pathway
purine-containing compound salvage
purine nucleobase metabolic process
purine nucleotide salvage
purine ribonucleoside monophosphate biosynthetic process
regulation of cell-cell adhesion mediated by integrin
response to drug
response to hydrogen peroxide
response to hypoxia
response to morphine
response to vitamin E
small molecule metabolic process
T cell activation
trophectodermal cell differentiation
xanthine biosynthetic process - Gene Ontology Molecular Function:
- adenosine deaminase activity
purine nucleoside binding
zinc ion binding - Gene Ontology Cellular Component:
- cell junction
cell surface
cytoplasm
cytoplasmic membrane-bounded vesicle lumen
cytosol
dendrite cytoplasm
external side of plasma membrane
extracellular space
lysosome
membrane
neuronal cell body
plasma membrane - Keywords:
- 3D-structure
Acetylation
Cell adhesion
Cell junction
Cell membrane
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Disease mutation
Hereditary hemolytic anemia
Hydrolase
Membrane
Metal-binding
Nucleotide metabolism
Polymorphism
Reference proteome
SCID
Zinc