Names & Taxonomy
- Uniprot ID:
- P00797
- Entry Name:
- RENI_HUMAN
- Status:
- reviewed
- Protein Names:
- Renin (EC 3.4.23.15) (Angiotensinogenase)
- Gene Names:
- REN
- Gene Names Primary:
- REN
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 406
- Sequence:
- MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.
Function
- Function:
- Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
- Catalytic Activity:
- Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1 uM for angiotensinogen (in absence of ATP6AP2); KM=0.15 uM for angiotensinogen (in presence of membrane-bound ATP6AP2);
- Enzyme Regulation:
- ENZYME REGULATION: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.
- Active Site:
- ACT_SITE 104 104; ACT_SITE 292 292
- Cross Reference Drug Bank:
- DB09026 DB00212
- Gene Ontology Go:
- extracellular region
extracellular space
lysosome
plasma membrane
aspartic-type endopeptidase activity
peptidase activity
receptor binding
angiotensin maturation
beta-amyloid metabolic process
cell maturation
cellular protein metabolic process
cellular response to drug
drinking behavior
hormone-mediated signaling pathway
kidney development
male gonad development
mesonephros development
proteolysis
regulation of blood pressure
regulation of MAPK cascade
renin-angiotensin regulation of aldosterone production
response to cAMP
response to cGMP
response to immobilization stress
response to lipopolysaccharide - Gene Ontology Biological Process:
- angiotensin maturation
beta-amyloid metabolic process
cell maturation
cellular protein metabolic process
cellular response to drug
drinking behavior
hormone-mediated signaling pathway
kidney development
male gonad development
mesonephros development
proteolysis
regulation of blood pressure
regulation of MAPK cascade
renin-angiotensin regulation of aldosterone production
response to cAMP
response to cGMP
response to immobilization stress
response to lipopolysaccharide - Gene Ontology Molecular Function:
- aspartic-type endopeptidase activity
peptidase activity
receptor binding - Gene Ontology Cellular Component:
- extracellular region
extracellular space
lysosome
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Aspartyl protease
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hydrolase
Membrane
Polymorphism
Protease
Reference proteome
Secreted
Signal
Zymogen