Names & Taxonomy

Uniprot ID:
P00742
Entry Name:
FA10_HUMAN
Status:
reviewed
Protein Names:
Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
Gene Names:
F10
Gene Names Primary:
F10
Organism:
Homo sapiens (Human)

Structure

Length:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Catalytic Activity:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Enzyme Regulation:
ENZYME REGULATION: Inhibited by SERPINA5 and SERPINA10.
Active Site:
ACT_SITE 276 276 Charge relay system.; ACT_SITE 322 322 Charge relay system.; ACT_SITE 419 419 Charge relay system.
Cross Reference Drug Bank:
DB00025 DB06605 DB00100 DB00036 DB09075 DB01225 DB00569 DB01109 DB00170 DB06228
Gene Ontology Go:
endoplasmic reticulum lumen
extracellular region
Golgi lumen
intrinsic component of external side of plasma membrane
plasma membrane
calcium ion binding
phospholipid binding
serine-type endopeptidase activity
blood coagulation
blood coagulation, extrinsic pathway
blood coagulation, intrinsic pathway
cellular protein metabolic process
ER to Golgi vesicle-mediated transport
peptidyl-glutamic acid carboxylation
positive regulation of cell migration
positive regulation of protein kinase B signaling
post-translational protein modification
signal peptide processing
Gene Ontology Biological Process:
blood coagulation
blood coagulation, extrinsic pathway
blood coagulation, intrinsic pathway
cellular protein metabolic process
ER to Golgi vesicle-mediated transport
peptidyl-glutamic acid carboxylation
positive regulation of cell migration
positive regulation of protein kinase B signaling
post-translational protein modification
signal peptide processing
Gene Ontology Molecular Function:
calcium ion binding
phospholipid binding
serine-type endopeptidase activity
Gene Ontology Cellular Component:
endoplasmic reticulum lumen
extracellular region
Golgi lumen
intrinsic component of external side of plasma membrane
plasma membrane
Keywords:
3D-structure
Blood coagulation
Calcium
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
Gamma-carboxyglutamic acid
Glycoprotein
Hemostasis
Hydrolase
Hydroxylation
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal
Zymogen

Publication

PubMed ID:
1902434 3768336 15489334 2582420 3011603 6871167 6587384 8243461 2612918 6323392 20427285 22171320 8355279 9618463 17227710 2790181 1973167 1985698 7669671 8529633 7860069 8845463 8910490 10468877 10391209 10746568 10739379 11248282 11728527 12945883 12574802 15075089 15650540 17393015 19135706 25313940 26222694