Names & Taxonomy
- Uniprot ID:
- P00736
- Entry Name:
- C1R_HUMAN
- Status:
- reviewed
- Protein Names:
- Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain]
- Gene Names:
- C1R
- Gene Names Primary:
- C1R
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 705
- Sequence:
- MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDTHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED
- Proteomes:
- UP000005640
Function
- Function:
- C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
- Catalytic Activity:
- Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).
- Active Site:
- ACT_SITE 502 502 Charge relay system.; ACT_SITE 557 557 Charge relay system.; ACT_SITE 654 654 Charge relay system.
- Cross Reference Drug Bank:
- DB00054 DB00051 DB00092 DB00087 DB00074 DB00112 DB00002 DB00111 DB00095 DB00005 DB00056 DB00078 DB00075 DB00108 DB00110 DB00073 DB00081 DB00072
- Gene Ontology Go:
- blood microparticle
extracellular exosome
extracellular region
calcium ion binding
serine-type endopeptidase activity
serine-type peptidase activity
complement activation
complement activation, classical pathway
immune response
innate immune response - Gene Ontology Biological Process:
- complement activation
complement activation, classical pathway
immune response
innate immune response - Gene Ontology Molecular Function:
- calcium ion binding
serine-type endopeptidase activity
serine-type peptidase activity - Gene Ontology Cellular Component:
- blood microparticle
extracellular exosome
extracellular region - Keywords:
- 3D-structure
Complement pathway
Complete proteome
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Hydrolase
Hydroxylation
Immunity
Innate immunity
Phosphoprotein
Polymorphism
Protease
Reference proteome
Repeat
Serine protease
Signal
Sushi - Interacts With:
- P09871