Names & Taxonomy
- Uniprot ID:
- P00734
- Entry Name:
- THRB_HUMAN
- Status:
- reviewed
- Protein Names:
- Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
- Gene Names:
- F2
- Gene Names Primary:
- F2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 622
- Sequence:
- MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space.
Function
- Function:
- Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
- Catalytic Activity:
- Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by SERPINA5.
- Active Site:
- ACT_SITE 406 406 Charge relay system.; ACT_SITE 462 462 Charge relay system.; ACT_SITE 568 568 Charge relay system.
- Cross Reference Drug Bank:
- DB00025 DB00278 DB05777 DB00006 DB00100 DB06695 DB00055 DB00001 DB00170 DB01123 DB04786 DB04898
- Gene Ontology Go:
- blood microparticle
endoplasmic reticulum lumen
extracellular exosome
extracellular matrix
extracellular region
extracellular space
Golgi lumen
plasma membrane
calcium ion binding
growth factor activity
receptor binding
serine-type endopeptidase activity
thrombospondin receptor activity
acute-phase response
blood coagulation
blood coagulation, intrinsic pathway
cell surface receptor signaling pathway
cellular protein metabolic process
cellular response to mechanical stimulus
ER to Golgi vesicle-mediated transport
fibrinolysis
leukocyte migration
multicellular organism development
negative regulation of astrocyte differentiation
negative regulation of fibrinolysis
negative regulation of platelet activation
negative regulation of proteolysis
peptidyl-glutamic acid carboxylation
platelet activation
positive regulation of blood coagulation
positive regulation of cell growth
positive regulation of cell proliferation
positive regulation of collagen biosynthetic process
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of protein phosphorylation
positive regulation of reactive oxygen species metabolic process
positive regulation of release of sequestered calcium ion into cytosol
post-translational protein modification
proteolysis
regulation of blood coagulation
regulation of cell shape
regulation of cytosolic calcium ion concentration
regulation of gene expression
response to inactivity
response to wounding
signal peptide processing - Gene Ontology Biological Process:
- acute-phase response
blood coagulation
blood coagulation, intrinsic pathway
cell surface receptor signaling pathway
cellular protein metabolic process
cellular response to mechanical stimulus
ER to Golgi vesicle-mediated transport
fibrinolysis
leukocyte migration
multicellular organism development
negative regulation of astrocyte differentiation
negative regulation of fibrinolysis
negative regulation of platelet activation
negative regulation of proteolysis
peptidyl-glutamic acid carboxylation
platelet activation
positive regulation of blood coagulation
positive regulation of cell growth
positive regulation of cell proliferation
positive regulation of collagen biosynthetic process
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of protein phosphorylation
positive regulation of reactive oxygen species metabolic process
positive regulation of release of sequestered calcium ion into cytosol
post-translational protein modification
proteolysis
regulation of blood coagulation
regulation of cell shape
regulation of cytosolic calcium ion concentration
regulation of gene expression
response to inactivity
response to wounding
signal peptide processing - Gene Ontology Molecular Function:
- calcium ion binding
growth factor activity
receptor binding
serine-type endopeptidase activity
thrombospondin receptor activity - Gene Ontology Cellular Component:
- blood microparticle
endoplasmic reticulum lumen
extracellular exosome
extracellular matrix
extracellular region
extracellular space
Golgi lumen
plasma membrane - Keywords:
- 3D-structure
Acute phase
Blood coagulation
Calcium
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Gamma-carboxyglutamic acid
Glycoprotein
Hemostasis
Hydrolase
Kringle
Pharmaceutical
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal
Thrombophilia
Zymogen - Interacts With:
- Q846V4; P07204
Publication
- PubMed ID:
- 2825773 14962227 14702039 15489334 6305407 8073540 266717 873923 6323392 3759958 2856554 11506076 15534175 14760718 15885491 16335952 17244316 19159218 19139490 19838169 22171320 24275569 2583108 2369893 2374926 8251938 8071320 9214615 10051558 11493008 16763681 17685615 18291642 18362344 6405779 3771562 3567158 3801671 3242619 2719946 1354985 1421398 1349838 7865694 7792730 10391209 22028381