Names & Taxonomy

Uniprot ID:
P00558
Entry Name:
PGK1_HUMAN
Status:
reviewed
Protein Names:
Phosphoglycerate kinase 1 (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2)
Gene Names:
PGK1 PGKA MIG10 OK/SW-cl.110
Gene Names Orf:
MIG10 OK/SW-cl.110
Gene Names Primary:
PGK1
Organism:
Homo sapiens (Human)

Structure

Length:
417
Sequence:
MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959).
Pathway:
Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.
Catalytic Activity:
ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.
Cross Reference Drug Bank:
DB00709
Gene Ontology Go:
cytosol
extracellular exosome
membrane
membrane raft
ATP binding
phosphoglycerate kinase activity
canonical glycolysis
carbohydrate metabolic process
epithelial cell differentiation
gluconeogenesis
glucose metabolic process
phosphorylation
small molecule metabolic process
Gene Ontology Biological Process:
canonical glycolysis
carbohydrate metabolic process
epithelial cell differentiation
gluconeogenesis
glucose metabolic process
phosphorylation
small molecule metabolic process
Gene Ontology Molecular Function:
ATP binding
phosphoglycerate kinase activity
Gene Ontology Cellular Component:
cytosol
extracellular exosome
membrane
membrane raft
Keywords:
3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Glycolysis
Hereditary hemolytic anemia
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Interacts With:
P04406

Publication

PubMed ID:
6188151 2995995 14702039 15772651 15489334 6099325 2814502 7391027 2324090 9075577 15592455 17081983 18669648 19608861 20068231 21269460 21908771 21406692 22814378 24275569 25944712 26677959 18463139 8673469 8043870 8615693 9744480 2001457 1586722 7391028 7440217 1547346 6941312 6933565