Names & Taxonomy
- Uniprot ID:
- P00558
- Entry Name:
- PGK1_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphoglycerate kinase 1 (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2)
- Gene Names:
- PGK1 PGKA MIG10 OK/SW-cl.110
- Gene Names Orf:
- MIG10 OK/SW-cl.110
- Gene Names Primary:
- PGK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 417
- Sequence:
- MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959).
- Pathway:
- Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.
- Catalytic Activity:
- ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.
- Cross Reference Drug Bank:
- DB00709
- Gene Ontology Go:
- cytosol
extracellular exosome
membrane
membrane raft
ATP binding
phosphoglycerate kinase activity
canonical glycolysis
carbohydrate metabolic process
epithelial cell differentiation
gluconeogenesis
glucose metabolic process
phosphorylation
small molecule metabolic process - Gene Ontology Biological Process:
- canonical glycolysis
carbohydrate metabolic process
epithelial cell differentiation
gluconeogenesis
glucose metabolic process
phosphorylation
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
phosphoglycerate kinase activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
membrane
membrane raft - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Glycolysis
Hereditary hemolytic anemia
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase - Interacts With:
- P04406