Names & Taxonomy
- Uniprot ID:
- P00491
- Entry Name:
- PNPH_HUMAN
- Status:
- reviewed
- Protein Names:
- Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase)
- Gene Names:
- PNP NP
- Gene Names Primary:
- PNP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 289
- Sequence:
- MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton
Function
- Function:
- The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
- Pathway:
- Purine metabolism; purine nucleoside salvage.
- Catalytic Activity:
- Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
- Cross Reference Drug Bank:
- DB00242 DB00900
- Gene Ontology Go:
- cytoplasm
cytoskeleton
cytosol
extracellular exosome
intracellular
nucleus
drug binding
nucleoside binding
phosphate ion binding
purine nucleobase binding
purine-nucleoside phosphorylase activity
immune response
inosine catabolic process
interleukin-2 secretion
NAD biosynthesis via nicotinamide riboside salvage pathway
nicotinamide riboside catabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
positive regulation of alpha-beta T cell differentiation
positive regulation of T cell proliferation
purine nucleobase metabolic process
purine nucleotide catabolic process
purine-containing compound salvage
response to drug
small molecule metabolic process
urate biosynthetic process - Gene Ontology Biological Process:
- immune response
inosine catabolic process
interleukin-2 secretion
NAD biosynthesis via nicotinamide riboside salvage pathway
nicotinamide riboside catabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
positive regulation of alpha-beta T cell differentiation
positive regulation of T cell proliferation
purine-containing compound salvage
purine nucleobase metabolic process
purine nucleotide catabolic process
response to drug
small molecule metabolic process
urate biosynthetic process - Gene Ontology Molecular Function:
- drug binding
nucleoside binding
phosphate ion binding
purine nucleobase binding
purine-nucleoside phosphorylase activity - Gene Ontology Cellular Component:
- cytoplasm
cytoskeleton
cytosol
extracellular exosome
intracellular
nucleus - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Glycosyltransferase
Polymorphism
Reference proteome
Transferase