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Names & Taxonomy

Uniprot ID:: P00441
Entry Name:: SODC_HUMAN
Status:: reviewed
Protein Names:: Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1)
Gene Names:: SOD1
Gene Names Primary:: SOD1
Organism:: Homo sapiens (Human)

Structure

Length:: 154
Sequence:: MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Cytoplasm

Function

Function:: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic Activity:: 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
Cofactor:: COFACTOR: Name=Cu cation; Xref=ChEBI:CHEBI:23378;
Cross Reference Drug Bank:: DB00958 DB00515 DB00526 DB00163
Gene Ontology Go:: axon
cytoplasm
cytoplasmic vesicle
cytosol
dendrite cytoplasm
dense core granule
extracellular exosome
extracellular matrix
extracellular region
extracellular space
lysosome
mitochondrial intermembrane space
mitochondrial matrix
mitochondrion
myelin sheath
neuronal cell body
nucleoplasm
nucleus
peroxisome
protein complex
chaperone binding
copper ion binding
identical protein binding
protein homodimerization activity
protein phosphatase 2B binding
Rac GTPase binding
superoxide dismutase activity
zinc ion binding
activation of MAPK activity
anterograde axonal transport
auditory receptor cell stereocilium organization
blood coagulation
cell aging
cellular iron ion homeostasis
cellular response to ATP
cellular response to cadmium ion
cellular response to potassium ion
embryo implantation
glutathione metabolic process
heart contraction
hydrogen peroxide biosynthetic process
locomotory behavior
muscle cell cellular homeostasis
myeloid cell homeostasis
negative regulation of cholesterol biosynthetic process
negative regulation of neuron apoptotic process
neurofilament cytoskeleton organization
ovarian follicle development
peripheral nervous system myelin maintenance
placenta development
platelet activation
platelet degranulation
positive regulation of apoptotic process
positive regulation of catalytic activity
positive regulation of cytokine production
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of superoxide anion generation
reactive oxygen species metabolic process
regulation of blood pressure
regulation of GTPase activity
regulation of mitochondrial membrane potential
regulation of multicellular organism growth
regulation of organ growth
regulation of protein kinase activity
regulation of T cell differentiation in thymus
relaxation of vascular smooth muscle
removal of superoxide radicals
response to amphetamine
response to antibiotic
response to antipsychotic drug
response to axon injury
response to carbon monoxide
response to copper ion
response to drug
response to ethanol
response to heat
response to hydrogen peroxide
response to nutrient levels
response to organic substance
response to reactive oxygen species
response to superoxide
retina homeostasis
retrograde axonal transport
sensory perception of sound
spermatogenesis
superoxide anion generation
superoxide metabolic process
thymus development
transmission of nerve impulse
Gene Ontology Biological Process:: activation of MAPK activity
anterograde axonal transport
auditory receptor cell stereocilium organization
blood coagulation
cell aging
cellular iron ion homeostasis
cellular response to ATP
cellular response to cadmium ion
cellular response to potassium ion
embryo implantation
glutathione metabolic process
heart contraction
hydrogen peroxide biosynthetic process
locomotory behavior
muscle cell cellular homeostasis
myeloid cell homeostasis
negative regulation of cholesterol biosynthetic process
negative regulation of neuron apoptotic process
neurofilament cytoskeleton organization
ovarian follicle development
peripheral nervous system myelin maintenance
placenta development
platelet activation
platelet degranulation
positive regulation of apoptotic process
positive regulation of catalytic activity
positive regulation of cytokine production
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of superoxide anion generation
reactive oxygen species metabolic process
regulation of blood pressure
regulation of GTPase activity
regulation of mitochondrial membrane potential
regulation of multicellular organism growth
regulation of organ growth
regulation of protein kinase activity
regulation of T cell differentiation in thymus
relaxation of vascular smooth muscle
removal of superoxide radicals
response to amphetamine
response to antibiotic
response to antipsychotic drug
response to axon injury
response to carbon monoxide
response to copper ion
response to drug
response to ethanol
response to heat
response to hydrogen peroxide
response to nutrient levels
response to organic substance
response to reactive oxygen species
response to superoxide
retina homeostasis
retrograde axonal transport
sensory perception of sound
spermatogenesis
superoxide anion generation
superoxide metabolic process
thymus development
transmission of nerve impulse
Gene Ontology Molecular Function:: chaperone binding
copper ion binding
identical protein binding
protein homodimerization activity
protein phosphatase 2B binding
Rac GTPase binding
superoxide dismutase activity
zinc ion binding
Gene Ontology Cellular Component:: axon
cytoplasm
cytoplasmic vesicle
cytosol
dendrite cytoplasm
dense core granule
extracellular exosome
extracellular matrix
extracellular region
extracellular space
lysosome
mitochondrial intermembrane space
mitochondrial matrix
mitochondrion
myelin sheath
neuronal cell body
nucleoplasm
nucleus
peroxisome
protein complex
Keywords:: 3D-structure
Acetylation
Amyotrophic lateral sclerosis
Antioxidant
Complete proteome
Copper
Cytoplasm
Direct protein sequencing
Disease mutation
Disulfide bond
Lipoprotein
Metal-binding
Mitochondrion
Neurodegeneration
Nucleus
Oxidoreductase
Palmitate
Phosphoprotein
Reference proteome
Ubl conjugation
Zinc
Interacts With:: Itself; P26339; P16014; Q8TCX1

Names & Taxonomy

Structure

Subcellular location

Function

Publication