Names & Taxonomy
- Uniprot ID:
- P00338
- Entry Name:
- LDHA_HUMAN
- Status:
- reviewed
- Protein Names:
- L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59)
- Gene Names:
- LDHA PIG19
- Gene Names Orf:
- PIG19
- Gene Names Primary:
- LDHA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 332
- Sequence:
- MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Pathway:
- Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
- Catalytic Activity:
- (S)-lactate + NAD(+) = pyruvate + NADH.
- Active Site:
- ACT_SITE 193 193 Proton acceptor.
- Cross Reference Drug Bank:
- DB02701
- Gene Ontology Go:
- cytosol
extracellular exosome
membrane
nucleus
L-lactate dehydrogenase activity
NAD binding
cellular metabolic process
glycolytic process
lactate metabolic process
NAD metabolic process
positive regulation of apoptotic process
post-embryonic organ development
pyruvate metabolic process
response to cAMP
response to drug
response to estrogen
response to glucose
response to hydrogen peroxide
response to hypoxia
response to nutrient
small molecule metabolic process
substantia nigra development - Gene Ontology Biological Process:
- cellular metabolic process
glycolytic process
lactate metabolic process
NAD metabolic process
positive regulation of apoptotic process
post-embryonic organ development
pyruvate metabolic process
response to cAMP
response to drug
response to estrogen
response to glucose
response to hydrogen peroxide
response to hypoxia
response to nutrient
small molecule metabolic process
substantia nigra development - Gene Ontology Molecular Function:
- L-lactate dehydrogenase activity
NAD binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
membrane
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Glycogen storage disease
NAD
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation - Interacts With:
- P11142; P07195; Q499Y8