Names & Taxonomy
- Uniprot ID:
- P00156
- Entry Name:
- CYB_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit)
- Gene Names:
- MT-CYB COB CYTB MTCYB
- Gene Names Primary:
- MT-CYB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 380
- Sequence:
- MTPMRKTNPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
- Gene Encoded:
- Mitochondrion
Function
- Function:
- Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Gene Ontology Go:
- mitochondrial inner membrane
mitochondrial respiratory chain complex III
mitochondrion
electron carrier activity
metal ion binding
ubiquinol-cytochrome-c reductase activity
cellular metabolic process
hydrogen ion transmembrane transport
hyperosmotic salinity response
mitochondrial electron transport, ubiquinol to cytochrome c
organ regeneration
respiratory electron transport chain
response to cadmium ion
response to calcium ion
response to cobalamin
response to copper ion
response to drug
response to ethanol
response to glucagon
response to heat
response to hyperoxia
response to hypoxia
response to mercury ion
response to toxic substance
small molecule metabolic process - Gene Ontology Biological Process:
- cellular metabolic process
hydrogen ion transmembrane transport
hyperosmotic salinity response
mitochondrial electron transport, ubiquinol to cytochrome c
organ regeneration
respiratory electron transport chain
response to cadmium ion
response to calcium ion
response to cobalamin
response to copper ion
response to drug
response to ethanol
response to glucagon
response to heat
response to hyperoxia
response to hypoxia
response to mercury ion
response to toxic substance
small molecule metabolic process - Gene Ontology Molecular Function:
- electron carrier activity
metal ion binding
ubiquinol-cytochrome-c reductase activity - Gene Ontology Cellular Component:
- mitochondrial inner membrane
mitochondrial respiratory chain complex III
mitochondrion - Keywords:
- Cardiomyopathy
Cataract
Complete proteome
Deafness
Disease mutation
Electron transport
Heme
Iron
Leber hereditary optic neuropathy
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Polymorphism
Reference proteome
Respiratory chain
Transmembrane
Transmembrane helix
Transport