Names & Taxonomy
- Uniprot ID:
- O96009
- Entry Name:
- NAPSA_HUMAN
- Status:
- reviewed
- Protein Names:
- Napsin-A (EC 3.4.23.-) (Aspartyl protease 4) (ASP4) (Asp 4) (Napsin-1) (TA01/TA02)
- Gene Names:
- NAPSA NAP1 NAPA
- Gene Names Primary:
- NAPSA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 420
- Sequence:
- MSPPPLLQPLLLLLPLLNVEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPAHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALHAAIGGIPLLAGEYIILCSEIPKLPAVSFLLGGVWFNLTAHDYVIQTTRNGVRLCLSGFQALDVPPPAGPFWILGDVFLGTYVAVFDRGDMKSSARVGLARARTRGADLGWGETAQAQFPG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- May be involved in processing of pneumocyte surfactant precursors.
- Active Site:
- ACT_SITE 96 96
- Gene Ontology Go:
- alveolar lamellar body
extracellular exosome
extracellular space
lysosome
multivesicular body lumen
aspartic-type endopeptidase activity
endopeptidase activity
peptidase activity
cellular protein metabolic process
membrane protein proteolysis
protein catabolic process
proteolysis
surfactant homeostasis - Gene Ontology Biological Process:
- cellular protein metabolic process
membrane protein proteolysis
protein catabolic process
proteolysis
surfactant homeostasis - Gene Ontology Molecular Function:
- aspartic-type endopeptidase activity
endopeptidase activity
peptidase activity - Gene Ontology Cellular Component:
- alveolar lamellar body
extracellular exosome
extracellular space
lysosome
multivesicular body lumen - Keywords:
- Aspartyl protease
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Polymorphism
Protease
Reference proteome
Secreted
Signal
Zymogen