Names & Taxonomy
- Uniprot ID:
- O95970
- Entry Name:
- LGI1_HUMAN
- Status:
- reviewed
- Protein Names:
- Leucine-rich glioma-inactivated protein 1 (Epitempin-1)
- Gene Names:
- LGI1 EPT UNQ775/PRO1569
- Gene Names Orf:
- UNQ775/PRO1569
- Gene Names Primary:
- LGI1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 557
- Sequence:
- MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.
- Gene Ontology Go:
- cell junction
extracellular region
extracellular space
synapse
receptor binding
axon guidance
cell proliferation
nervous system development
neuron projection development
positive regulation of cell growth
positive regulation of synaptic transmission
protein homooligomerization - Gene Ontology Biological Process:
- axon guidance
cell proliferation
nervous system development
neuron projection development
positive regulation of cell growth
positive regulation of synaptic transmission
protein homooligomerization - Gene Ontology Molecular Function:
- receptor binding
- Gene Ontology Cellular Component:
- cell junction
extracellular region
extracellular space
synapse - Keywords:
- Alternative splicing
Cell junction
Complete proteome
Disease mutation
Epilepsy
Glycoprotein
Leucine-rich repeat
Reference proteome
Repeat
Secreted
Signal
Synapse