Names & Taxonomy
- Uniprot ID:
- O95954
- Entry Name:
- FTCD_HUMAN
- Status:
- reviewed
- Protein Names:
- Formimidoyltransferase-cyclodeaminase (Formiminotransferase-cyclodeaminase) (FTCD) (LCHC1) [Includes: Glutamate formimidoyltransferase (EC 2.1.2.5) (Glutamate formiminotransferase) (Glutamate formyltransferase); Formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) (Formiminotetrahydrofolate cyclodeaminase)]
- Gene Names:
- FTCD
- Gene Names Primary:
- FTCD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 541
- Sequence:
- MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGALDVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGARKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQLVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGSVAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEAMRLPKNTPEEKDRRTAALQEGLRRAVSVPLTLAETVASLWPALQELARCGNLACRSDLQVAAKALEMGVFGAYFNVLINLRDITDEAFKDQIHHRVSSLLQEAKTQAALVLDCLETRQE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Function
- Function:
- Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.; Binds and promotes bundling of vimentin filaments originating from the Golgi.
- Pathway:
- Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.; One-carbon metabolism; tetrahydrofolate interconversion.
- Catalytic Activity:
- 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.; 5-formyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formyl-L-glutamate.; 5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH(3).
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Active Site:
- ACT_SITE 82 82 For formimidoyltransferase activity.
- Cross Reference Drug Bank:
- DB00116
- Gene Ontology Go:
- centriole
cytoplasm
cytosol
endoplasmic reticulum
endoplasmic reticulum-Golgi intermediate compartment
extracellular exosome
Golgi apparatus
Golgi membrane
smooth endoplasmic reticulum membrane
folic acid binding
formimidoyltetrahydrofolate cyclodeaminase activity
formimidoyltransferase activity
glutamate formimidoyltransferase activity
microtubule binding
cellular nitrogen compound metabolic process
cytoskeleton organization
folic acid-containing compound metabolic process
histidine catabolic process
histidine catabolic process to glutamate and formamide
histidine catabolic process to glutamate and formate
small molecule metabolic process
tetrahydrofolate interconversion - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
cytoskeleton organization
folic acid-containing compound metabolic process
histidine catabolic process
histidine catabolic process to glutamate and formamide
histidine catabolic process to glutamate and formate
small molecule metabolic process
tetrahydrofolate interconversion - Gene Ontology Molecular Function:
- folic acid binding
formimidoyltetrahydrofolate cyclodeaminase activity
formimidoyltransferase activity
glutamate formimidoyltransferase activity
microtubule binding - Gene Ontology Cellular Component:
- centriole
cytoplasm
cytosol
endoplasmic reticulum
endoplasmic reticulum-Golgi intermediate compartment
extracellular exosome
Golgi apparatus
Golgi membrane
smooth endoplasmic reticulum membrane - Keywords:
- Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Folate-binding
Golgi apparatus
Histidine metabolism
Lyase
Multifunctional enzyme
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase - Interacts With:
- Q8N6L0; Q9NPJ6