Names & Taxonomy
- Uniprot ID:
- O95907
- Entry Name:
- MOT3_HUMAN
- Status:
- reviewed
- Protein Names:
- Monocarboxylate transporter 3 (MCT 3) (Solute carrier family 16 member 8)
- Gene Names:
- SLC16A8 MCT3
- Gene Names Primary:
- SLC16A8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 504
- Sequence:
- MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTEPEIEARPRLAAESV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
- Cross Reference Drug Bank:
- DB00119
- Gene Ontology Go:
- basal plasma membrane
integral component of plasma membrane
membrane
plasma membrane
lactate transmembrane transporter activity
symporter activity
blood coagulation
cellular metabolic process
lactate transport
leukocyte migration
plasma membrane lactate transport
pyruvate metabolic process
small molecule metabolic process
transmembrane transport - Gene Ontology Biological Process:
- blood coagulation
cellular metabolic process
lactate transport
leukocyte migration
plasma membrane lactate transport
pyruvate metabolic process
small molecule metabolic process
transmembrane transport - Gene Ontology Molecular Function:
- lactate transmembrane transporter activity
symporter activity - Gene Ontology Cellular Component:
- basal plasma membrane
integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Membrane
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport