Names & Taxonomy
- Uniprot ID:
- O95864
- Entry Name:
- FADS2_HUMAN
- Status:
- reviewed
- Protein Names:
- Fatty acid desaturase 2 (EC 1.14.19.3) (Acyl-CoA 6-desaturase) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase)
- Gene Names:
- FADS2
- Gene Names Primary:
- FADS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 444
- Sequence:
- MGKGGNQGEGAAEREVSVPTFSWEEIQKHNLRTDRWLVIDRKVYNITKWSIQHPGGQRVIGHYAGEDATDAFRAFHPDLEFVGKFLKPLLIGELAPEEPSQDHGKNSKITEDFRALRKTAEDMNLFKTNHVFFLLLLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWLQHDYGHLSVYRKPKWNHLVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHVFVLGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIIRSLKKSGKLWLDAYLHK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum.
- Pathway:
- Lipid metabolism; polyunsaturated fatty acid biosynthesis.
- Catalytic Activity:
- Linoleoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
- Cross Reference Drug Bank:
- DB00132
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of plasma membrane
membrane
linoleoyl-CoA desaturase activity
stearoyl-CoA 9-desaturase activity
alpha-linolenic acid metabolic process
linoleic acid metabolic process
small molecule metabolic process
unsaturated fatty acid biosynthetic process
unsaturated fatty acid metabolic process - Gene Ontology Biological Process:
- alpha-linolenic acid metabolic process
linoleic acid metabolic process
small molecule metabolic process
unsaturated fatty acid biosynthetic process
unsaturated fatty acid metabolic process - Gene Ontology Molecular Function:
- linoleoyl-CoA desaturase activity
stearoyl-CoA 9-desaturase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of plasma membrane
membrane - Keywords:
- Alternative splicing
Complete proteome
Electron transport
Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
Oxidoreductase
Reference proteome
Transmembrane
Transmembrane helix
Transport