Names & Taxonomy
- Uniprot ID:
- O95749
- Entry Name:
- GGPPS_HUMAN
- Status:
- reviewed
- Protein Names:
- Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
- Gene Names:
- GGPS1
- Gene Names Primary:
- GGPS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 300
- Sequence:
- MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
- Pathway:
- Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.; Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.; Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.
- Catalytic Activity:
- Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=3 uM for isopentenyl diphosphate
- Enzyme Regulation:
- ENZYME REGULATION: Subject to product inhibition by geranylgeranyl diphosphate.
- Cross Reference Drug Bank:
- DB00399
- Gene Ontology Go:
- cytosol
dimethylallyltranstransferase activity
farnesyltranstransferase activity
geranyltranstransferase activity
metal ion binding
cholesterol biosynthetic process
farnesyl diphosphate biosynthetic process
geranyl diphosphate biosynthetic process
geranylgeranyl diphosphate biosynthetic process
isoprenoid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- cholesterol biosynthetic process
farnesyl diphosphate biosynthetic process
geranyl diphosphate biosynthetic process
geranylgeranyl diphosphate biosynthetic process
isoprenoid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- dimethylallyltranstransferase activity
farnesyltranstransferase activity
geranyltranstransferase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Isoprene biosynthesis
Magnesium
Metal-binding
Reference proteome
Transferase - Interacts With:
- O00244