Names & Taxonomy

Uniprot ID:
O95674
Entry Name:
CDS2_HUMAN
Status:
reviewed
Protein Names:
Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2)
Gene Names:
CDS2
Gene Names Primary:
CDS2
Organism:
Homo sapiens (Human)

Structure

Length:
445
Sequence:
MTELRQRVAHEPVAPPEDKESESEAKVDGETASDSESRAESAPLPVSADDTPEVLNRALSNLSSRWKNWWVRGILTLAMIAFFFIIIYLGPMVLMIIVMCVQIKCFHEIITIGYNVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFTLYLIGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLFEGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLLSYVMSGYRCFVCPVEYNNDTNSFTVDCEPSDLFRLQEYNIPGVIQSVIGWKTVRMYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKLIQQFLTLRPDQQLHIFNTLRSHLIDKGMLTSTTEDE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion inner membrane

Function

Function:
Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.
Pathway:
Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Catalytic Activity:
CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
membrane
mitochondrial inner membrane
phosphatidate cytidylyltransferase activity
CDP-diacylglycerol biosynthetic process
glycerophospholipid biosynthetic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
CDP-diacylglycerol biosynthetic process
glycerophospholipid biosynthetic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
phosphatidate cytidylyltransferase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
membrane
mitochondrial inner membrane
Keywords:
Alternative splicing
Complete proteome
Lipid biosynthesis
Lipid metabolism
Membrane
Mitochondrion
Mitochondrion inner membrane
Nucleotidyltransferase
Phospholipid biosynthesis
Phospholipid metabolism
Phosphoprotein
Reference proteome
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
9889000 14702039 11780052 15489334 9806839 17081983 18088087 18691976 18669648 18318008 19690332 20068231 21406692 24275569