Names & Taxonomy
- Uniprot ID:
- O95674
- Entry Name:
- CDS2_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2)
- Gene Names:
- CDS2
- Gene Names Primary:
- CDS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 445
- Sequence:
- MTELRQRVAHEPVAPPEDKESESEAKVDGETASDSESRAESAPLPVSADDTPEVLNRALSNLSSRWKNWWVRGILTLAMIAFFFIIIYLGPMVLMIIVMCVQIKCFHEIITIGYNVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFTLYLIGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLFEGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLLSYVMSGYRCFVCPVEYNNDTNSFTVDCEPSDLFRLQEYNIPGVIQSVIGWKTVRMYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKLIQQFLTLRPDQQLHIFNTLRSHLIDKGMLTSTTEDE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
Function
- Function:
- Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.
- Pathway:
- Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
- Catalytic Activity:
- CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
membrane
mitochondrial inner membrane
phosphatidate cytidylyltransferase activity
CDP-diacylglycerol biosynthetic process
glycerophospholipid biosynthetic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- CDP-diacylglycerol biosynthetic process
glycerophospholipid biosynthetic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- phosphatidate cytidylyltransferase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
membrane
mitochondrial inner membrane - Keywords:
- Alternative splicing
Complete proteome
Lipid biosynthesis
Lipid metabolism
Membrane
Mitochondrion
Mitochondrion inner membrane
Nucleotidyltransferase
Phospholipid biosynthesis
Phospholipid metabolism
Phosphoprotein
Reference proteome
Transferase
Transmembrane
Transmembrane helix